Encephalitis Antibody Evaluation with Reflex to Titer and Line Blot, CSF
Test code
CPT code(s)*
Details
Includes
If Encephalitis Antibody Screen, Tissue IFA suggests a fluorescence pattern consistent with one or more antibodies including AGNA1 (SOX1), Amphiphysin, ANNA1 (Hu), ANNA2 (Ri), CRMP5(CV2), GAD65, Ma2/Ta, PCA1 (Yo), PCA Tr (DNER), and Zic4, then a line blot consisting of these 10 antibodies will be performed.
If Encephalitis Antibody Screen, Tissue IFA suggests a fluorescence pattern consistent with ANNA3, then titer will be performed.
If Encephalitis Antibody Screen, Tissue IFA suggests a fluorescence pattern consistent with PCA2, then titer will be performed.
If Encephalitis Antibody Screen, Tissue IFA suggests a fluorescence pattern consistent with PCA Tr (DNER) and Neurology Antibody Line Blot shows PCA Tr (DNER) Negative and PCA1 (Yo) Negative, then PCA Tr (DNER) Ab, CBA, CSF will be performed at an additional charge (CPT code(s): 86255).
If PCA Tr (DNER) Ab, CBA, CSF is Positive, then titer will be performed.
If Encephalitis Antibody Screen, Tissue IFA for Myelin suggests a fluorescence pattern consistent with Myelin Antibody, then titer will be performed at an additional charge (CPT code(s): 86256).
If Neurology Antibody, CBA is Positive for NMDAR1, AMPAR2, LGI1, or CASPR2, then titers will be performed at an additional charge (CPT code(s): 86256 for each titer performed).
If Aquaporin 4 (AQP4) Ab, CBA is Positive, then titer will be performed at an additional charge (CPT code (s): 86052).
If Neurology Antibody, CBA is Positive for AMPAR1 or GABABR, then titers will be performed.
If DPPX Antibody, CBA is Positive, then titer will be performed.
Alternative name(s)
Encephalitis panel,Autoimmune panel,Encephalopathy-Autoimmune Eval, CSF,Autoimmune Encephalitis Panel,Neurology,Neuroimmunology
Specimen requirements | |
|---|---|
| Patient preparation | None Specified |
| Preferred specimen(s) | 4 mL CSF collected in a sterile leak-proof container |
| Minimum volume | 2 mL |
| Transport container | Sterile leak-proof container |
| Transport temperature | Refrigerated (cold packs) |
| Specimen stability | Room temperature: 24 hours Refrigerated: 7 days Frozen: 21 days |
| Reject criteria | Received room temperature |
Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.
*The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.
This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.
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