LRP4 Autoantibody Test

LRP4 Autoantibody Test

Test Code

94744
86255
94744
86255
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection may be available in your area for purchase through Quest Mobile.

Clinical Significance

LRP4 Autoantibody Test - Detects anti-LRP4 (low density lipoprotein receptor-related protein 4) in the sera of patients with Myasthenia Gravis (MG). The LRP4 protein activates MuSK kinase activity and promotes the clustering of AChR and their stabilization at the NMJ. Anti-LRP4 antibodies are found in approximately 9.2% (range 2% to 50%) of MG patients who are negative for both anti-AChR and anti-MuSK.

Test Resources

Algorithm

Selection of Antibody Tests in the Confirmation and Assessment of Suspected Generalized Myasthenia Gravis

Algorithm

Selection of Antibody Tests in the Confirmation and Assessment of Suspected Ocular Myasthenia Gravis

Clinical Focus

Myasthenia Gravis and Autoantibodies

Test Details

Methodology

Immunofluorescence Assay (IFA)

Reference Range(s)

See Laboratory Report

LOINC® Codes, Performing Laboratory

Service Area must be determined

Methodology

Immunofluorescence Assay (IFA)

Reference Range(s)

See Laboratory Report
Service Area must be determined

Preferred Specimen(s)

2 mL serum

Minimum Volume

0.5 mL

Collection Instructions

Please label each specimen tube with two forms of patient identification. These forms of identification must also appear on the requisition form.

Transport Container

Transport tube

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

  • Room temperature: 72 hours
  • Refrigerated: 25 days
  • Frozen: 25 days

Setup Schedule

Service Area must be determined
2 mL serum
0.5 mL
Please label each specimen tube with two forms of patient identification. These forms of identification must also appear on the requisition form.
Transport tube
Refrigerated (cold packs)
Room temperature: 72 hours
Refrigerated: 25 days
Frozen: 25 days
Service Area must be determined
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection may be available in your area for purchase through Quest Mobile.
Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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