18-Hydroxycorticosterone

18-Hydroxycorticosterone

Test Code

94621
82528
94621
82528
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection is not available in your area through Quest Mobile.

Clinical Significance

18-Hydroxycorticosterone - Primary aldosteronism should be suspected whenever a patient has the triad of hypertension, hypokalemia, and inappropriate renal potassium wasting. The biggest challenge is the differential diagnosis between the more common adrenal adenoma and bilateral hyperplasia. Because adrenal adenomas increase the circulating levels of 18-hydroxycorticosterone (18-OH B), serum levels of 18-OH B may be useful to differentiate them from bilateral adrenal hyperplasia. The cutoff point appears to be about 50 ng/dL of serum. Most values are around 100 ng/dL. The higher the level of this precursor, the greater the possibility that an adrenal adenoma is present.
J Clin Endocrinol Metab. 97: 881-9, 2012.

Test Resources

None found for this test
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Test Details

Methodology

Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)

Assay Category

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

Adult

Males≤175 ng/dL
Females 
  Pre-Menopausal Mid Follicular≤98 ng/dL
  Pre-Menopausal Surge≤152 ng/dL
  Pre-Menopausal Mid Luteal36-164 ng/dL

Pediatric
<30 daysNot established
1-11 months≤165 ng/dL
1 year≤140 ng/dL
2 years≤129 ng/dL
3 years≤128 ng/dL
4 years≤133 ng/dL
5 years≤142 ng/dL
6 years≤151 ng/dL
7 years≤160 ng/dL
8 years≤164 ng/dL
9 years≤166 ng/dL
10 years≤165 ng/dL
11 years≤163 ng/dL
12 years≤159 ng/dL
13 years≤155 ng/dL
14 years≤151 ng/dL
15 years≤146 ng/dL
16 years≤142 ng/dL
17 years≤138 ng/dL

Alternative Name(s)

18-OH Corticosterone

LOINC® Codes, Performing Laboratory

Service Area must be determined

Methodology

Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

Adult
Males≤175 ng/dL
Females 
  Pre-Menopausal Mid Follicular≤98 ng/dL
  Pre-Menopausal Surge≤152 ng/dL
  Pre-Menopausal Mid Luteal36-164 ng/dL

Pediatric
<30 daysNot established
1-11 months≤165 ng/dL
1 year≤140 ng/dL
2 years≤129 ng/dL
3 years≤128 ng/dL
4 years≤133 ng/dL
5 years≤142 ng/dL
6 years≤151 ng/dL
7 years≤160 ng/dL
8 years≤164 ng/dL
9 years≤166 ng/dL
10 years≤165 ng/dL
11 years≤163 ng/dL
12 years≤159 ng/dL
13 years≤155 ng/dL
14 years≤151 ng/dL
15 years≤146 ng/dL
16 years≤142 ng/dL
17 years≤138 ng/dL

Alternative Name(s)

18-OH Corticosterone
Service Area must be determined

Preferred Specimen(s)

0.5 mL serum collected in a red-top tube (no gel)

Minimum Volume

0.25 mL

Collection Instructions

Collect specimen in a non-additive red-top tube. Spin down immediately and pour off into a 13 x 75 mm plastic tranport tube.

Transport Container

Transport tube

Transport Temperature

Frozen

Specimen Stability

  • Room temperature: 7 days
  • Refrigerated: 7 days
  • Frozen: 28 days

Reject Criteria

Gross and moderate hemolysis • Grossly lipemic • Serum separator tube (SST) • Grossly icteric

Setup Schedule

Service Area must be determined
0.5 mL serum collected in a red-top tube (no gel)
0.25 mL
Collect specimen in a non-additive red-top tube. Spin down immediately and pour off into a 13 x 75 mm plastic tranport tube.
Transport tube
Frozen
Room temperature: 7 days
Refrigerated: 7 days
Frozen: 28 days
Gross and moderate hemolysis • Grossly lipemic • Serum separator tube (SST) • Grossly icteric
Service Area must be determined
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection is not available in your area through Quest Mobile.
Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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