Voriconazole
Test Code
94096
80285
Clinical Significance
Voriconazole - The antifungal drug voriconazole is commonly used in the treatment of various types of fungal infections. An increased fungal resistance to similar drugs of greater toxicity has promoted the use of voriconazole in treating infections caused by aspergillus and other fungal species. The chronic nature of fungal infections demands constant monitoring of voriconazole levels within a patient to ensure that adequate therapeutic levels of the drug are administered, absorbed and subsequently excreted.
Test Details
Methodology
Chromatography/Mass Spectrometry
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Reference Range(s)
Steady state trough levels are achieved within 1 day when an IV loading dose is used and after approximately 5 days of oral or IV therapy without a loading dose.
Therapeutic range
Prophylaxis: trough >0.5 mcg/mL
Therapeutic range for treatment: trough 2.0-5.5 mcg/mL
Serum trough levels ≥1 mcg/mL are reported to be associated with lack of therapeutic response and serum trough levels >5.5 mcg/mL have been reported to be associated with reversible neurological adverse events and hepatotoxicity.
Co-administration of drugs that metabolically induce or inhibit CYP2C19, or other conditions that affect CYP2C19 may alter voriconazole metabolism.
Therapeutic range
Prophylaxis: trough >0.5 mcg/mL
Therapeutic range for treatment: trough 2.0-5.5 mcg/mL
Serum trough levels ≥1 mcg/mL are reported to be associated with lack of therapeutic response and serum trough levels >5.5 mcg/mL have been reported to be associated with reversible neurological adverse events and hepatotoxicity.
Co-administration of drugs that metabolically induce or inhibit CYP2C19, or other conditions that affect CYP2C19 may alter voriconazole metabolism.
Preferred Specimen(s)
2 mL serum collected in a red-top tube (no gel)
Alternative Specimen(s)
Plasma collected in: Sodium heparin (green-top) tube
Minimum Volume
1 mL
Transport Container
Transport tube
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
- Room temperature: 5 days
- Refrigerated: 5 days
- Frozen: 30 days
Reject Criteria
Serum separator tubes (SST) • Other body fluids
Setup Schedule
2 mL serum collected in a red-top tube (no gel)
Plasma collected in: Sodium heparin (green-top) tube
1 mL
Transport tube
Refrigerated (cold packs)
Room temperature: 5 days
Refrigerated: 5 days
Frozen: 30 days
Refrigerated: 5 days
Frozen: 30 days
Serum separator tubes (SST) • Other body fluids