Autoimmune Neurology Antibody Comprehensive Panel with Reflexes, Serum
Test code
CPT code(s)*
Clinical significance
Test resources
Test FAQ
Details
Includes
Initial panel consist of: Neurology Ab Screen Tissue IFA, AMPAR1, AMPAR2, DPPX, GABAbR, NMDAR1, CASPAR2, LGI1, ANNA1 (Hu), ANNA2 (RI), PCA1 (YO), MA/TA, CRMP5 (CV2), Amphiphysin, GAD65, Recoverin, AGNA (SOX1), Titin, Zic4, PCA TR (DNER) and AChr Binding Antibody, Ganglionic AChR, Anti-Striated Muscle Antibody Screen, VGCC N-Type, VGCC P/Q-Type, and VGKC.
If Autoimmune Neurology Antibody Comprehensive Panel suggests NMO-5 IgG, then Aquaporin-4 Antibody will be performed at an additional charge (CPT code(s): 86052).
If Aquaporin-4 Ab is positive, then titer will be performed at an additional charge (CPT code(s): 86052).
If Autoimmune Neurology Antibody Comprehensive Panel suggests ANNA-3, then titer will be performed at an additional charge (CPT code(s): 86256).
If Autoimmune Neurology Antibody Comprehensive Panel suggests PCA2, then titer will be performed at an additional charge (CPT code(s): 86256).
If Autoimmune Neurology Antibody Comprehensive Panel suggests PCA-Tr and Paraneoplastic Ab, WB shows DNER negative and Yo Negative, then DNER, Ab, IFA will be performed at an additional charge (CPT code(s): 86255).
If DNER, Ab, IFA is positive, then a titer will be performed at an additional charge (CPT code(s): 86256).
If Autoimmune Neurology Antibody Comprehensive Panel suggests Myelin Antibody, then Myelin Ab titer will be performed at an additional charge (CPT code(s): 86256), and Myelin Assoc. Glycoprotein (MAG) Antibody w/Reflex to MAG-SGPG & MAG, EIA will be performed at an additional charge (CPT code(s): 84182, 83520 x2).
If MAG Antibody (IgM), Western Blot is positive, then both MAG-SGPG Antibody (IgM), EIA and MAG Antibody (IgM), EIA will be performed at additional charge (CPT code(s): 83520 x2).
If NMDAR1 Ab is positive, then a titer will be performed at an additional charge (CPT code(s): 86256).
If AMPAR1 Ab is positive, then a titer will be performed at an additional charge (CPT code(s): 86256).
If AMPAR2 Ab is positive, then a titer will be performed at an additional charge (CPT code(s): 86256).
If LGI-1 Ab is positive, then a titer will be performed at an additional charge (CPT code(s): 86256).
If CASPR2 Ab is positive, then a titer will be performed at an additional charge (CPT code(s): 86256).
If DPPX Ab is positive, then a titer will be performed at an additional charge (CPT code(s): 86256).
If GABA-B Receptor Ab is positive, then a titer will be performed at an additional charge (CPT code(s): 86256).
If AChR Binding is Negative, then AChR Modulating Ab will be performed at an additional charge (CPT code(s): 86043).
If AChR Binding is Positive (≥0.50), then AChR Blocking Ab will be performed at an additional charge (CPT code(s): 86042).
If AChR Binding is Equivocal (0.31-0.49), then both AChR Blocking and AChR Modulating will be performed at additional charge (CPT code(s): 86042, 86043).
If Anti-Striated Muscle Ab Screen is Positive, then Anti-Striated Muscle Ab Titer will be performed at an additional charge (CPT code(s): 86256).
Methodology
See individual tests
Assay category
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Alternative name(s)
Paraneoplastic Abs, Serum, Comprehensive,Comprehensive Paraneoplastic Panel
Specimen requirements | |
|---|---|
| Patient preparation | None Specified |
| Preferred specimen(s) | 10 mL serum collected in a red-top tube (no gel) |
| Minimum volume | 5 mL |
| Transport container | Transport tube(s) |
| Transport temperature | Refrigerated (cold packs) |
| Specimen stability | Room temperature: 48 hours Refrigerated: 14 days Frozen: 21 days |
| Reject criteria | Serum separator tube (SST) |
Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.
*The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.
This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.
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