Myasthenia Gravis Panel 2 with Reflex to MuSK Antibody

Myasthenia Gravis Panel 2 with Reflex to MuSK Antibody

Test Code

93859
86041, 86042, 86043
93859
86041, 86042, 86043
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection may be available in your area for purchase through Quest Mobile.

Clinical Significance

Myasthenia Gravis Panel 2 with Reflex to MuSK Antibody - Myasthenia gravis (MG) is an autoimmune disorder affecting the neuromuscular junction. 80% of patients with generalized MG have serum antibodies to AChR - Blocking, Binding, or Modulating. Antibodies to MuSK make up a variable proportion of the remaining 20%.

Test Details

Includes

  • Acetylcholine Receptor Blocking Antibody
    Acetylcholine Receptor Binding Antibody
    Acetylcholine Receptor Modulating Antibody

    If AChR blocking is <15% of inhibition, AChR binding is ≤0.30 nmol/L, and AChR modulating is <32% binding inhibition, then MuSK Antibody Test will be performed at an additional charge (CPT code(s) 86366).

Methodology

Immunoassay (IA)

Assay Category

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

See Laboratory Report

LOINC® Codes, Performing Laboratory

Acetylcholine Receptor Blocking Antibody
Acetylcholine Receptor Binding Antibody
Acetylcholine Receptor Modulating Antibody

If AChR blocking is <15% of inhibition, AChR binding is ≤0.30 nmol/L, and AChR modulating is <32% binding inhibition, then MuSK Antibody Test will be performed at an additional charge (CPT code(s) 86366).

Methodology

Immunoassay (IA)
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

See Laboratory Report

Preferred Specimen(s)

3 mL serum

Minimum Volume

0.7 mL

Transport Container

Transport tube

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

  • Room temperature: 7 days
    Refrigerated: 14 days
    Frozen: 30 days

Reject Criteria

Hemolysis • Lipemia • Microbially contaminated

Setup Schedule

3 mL serum
0.7 mL
Transport tube
Refrigerated (cold packs)
Room temperature: 7 days
Refrigerated: 14 days
Frozen: 30 days
Hemolysis • Lipemia • Microbially contaminated
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection may be available in your area for purchase through Quest Mobile.
Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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