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Protein S Activity, Antigen, Total and Free

Test code

93355

CPT code(s)*

85305, 85306 (x2)
Notices
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide Service Area Information to find available tests you can order.
In-home collection is not available in your area through Quest Mobile.

Clinical significance

Protein S Activity, Antigen, Total and Free - Protein S deficiency may either be hereditary or acquired and is associated with an increased risk forvenous thromboembolic disease. Congenital Protein S (PS) deficiency may be classified based on the PS Antigen (Free and Total) and activity results. Type I deficiency is characterized by a decrease in antigen and activity levels whereas a Type II deficiency will have normal antigen levels but reduced activity. A third classification, Type III deficiency, is characterized by reduced free PS antigen and activity, but normal total PS antigen levels associated with increased C4b binding protein level.Anticoagulant interference: Expected…
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Test resources

None found for this test
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Details

Test details

Includes

Protein S Antigen, Total
Protein S Antigen, Free
Protein S Activity

Methodology

Clotting Assay • Immunoturbidimetric Assay

Alternative name(s)

PS,Protein S,Protein S Functional,PS Antigen,PS Free

Specimen requirements
Patient preparationNone Specified
Preferred specimen(s)1 mL plasma collected in each of two 3.2 % separate sodium citrate (light blue-top) tubes
Minimum volume0.5 mL per specimen
Collection instructionsPlease submit a separate, frozen vial for each special coagulation assay ordered. Draw blood in a light blue-top tube containing 3.2% sodium citrate, mix gently by inverting 3-4 times. Centrifuge 15 minutes at 1500 g within one hour of collection. Using a plastic pipette, remove plasma, taking care to avoid the WBC/platelet buffy layer and place into a plastic vial. Centrifuge a second time and transfer platelet-poor plasma into a new plastic vial(s). Freeze immediately and transport on dry ice.
Transport containerTransport tube(s)
Transport temperatureFrozen
Specimen stabilityRoom temperature: Unacceptable
Refrigerated: Unacceptable
Frozen: 30 days
Reject criteriaHemolysis
Service Area Information
Service Area Information

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

*The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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