Alpha Synuclein (SNCA) DNA Sequencing Test
Test Code
Clinical Significance
Alpha Synuclein (SNCA) DNA Sequencing Test - Detects mutations in SNCA.
Typical Presentation: Cardinal symptoms of Parkinsonism, including resting tremor, postural instability, rigidity, and bradykinesia. Atypical features may also be present, such as depression, dementia, and hallucinations. Indications for testing: Juvenile-Onset PD regardless of family history, Early Onset PD with atypical parkinsonism, Early Onset PD with a positive family history, and Late Onset PD with a positive family history.
Test Resources
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Test Details
Preferred Specimen(s)
8 mL whole blood collected in two EDTA (lavender-top) tubes
Minimum Volume
6 mL
Collection Instructions
Please label each specimen with two forms of patient identification. These forms of identification must also appear on the requisition form.
Note: Higher blood volumes ensure adequate DNA quantity, which varies with WBC, specimen condition, and need for confirmatory testing.
Transport Container
EDTA (lavender-top) tube
Transport Temperature
Room temperature
Specimen Stability
- Room temperature: 10 days
- Refrigerated: 10 days
- Frozen: Unacceptable
Setup Schedule
Note: Higher blood volumes ensure adequate DNA quantity, which varies with WBC, specimen condition, and need for confirmatory testing.
Refrigerated: 10 days
Frozen: Unacceptable