Solid Tumor Expanded Panel

Solid Tumor Expanded Panel

Test Code

93233
0379U
93233
0379U
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection is not available in your area through Quest Mobile.

Clinical Significance

Solid Tumor Expanded Panel - Solid Tumor Genomics from Quest Advanced Diagnostics - Precision medicine is an emerging approach for disease prevention and treatment that takes individual variability into account. This next-generation sequencing (NGS) panel along with the computational resources and tools that process and analyze the data, allows the characterization of individual patients and tumor types. Guidelines exist for using results from many of these genes for selection of FDA approved therapies. This NGS panel can accurately and sensitively sequence more target genes with less DNA, with reduced cost, time and labor ...

Test Resources

Test FAQ

Solid Tumor Expanded Panel

Clinical Focus

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Topic Brief

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Topic Brief

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Test Summary

Solid Tumor Expanded Panel

Test Details

Methodology

Next Generation Sequencing

Assay Category

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

See Laboratory Report

Alternative Name(s)

Cancer Genomics, NGS, Tumor Profiling, 500, STEP500, Cancer Therapy, Therapy Selection, Cancer Research, Cancer Discovery

LOINC® Codes, Performing Laboratory

Service Area must be determined

Methodology

Next Generation Sequencing
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

See Laboratory Report

Alternative Name(s)

Cancer Genomics, NGS, Tumor Profiling, 500, STEP500, Cancer Therapy, Therapy Selection, Cancer Research, Cancer Discovery
Service Area must be determined

Preferred Specimen(s)

200 mm2, ≥20% tumor content of tumor tissue collected in a formalin-fixed, paraffin-embedded tissue

Alternative Specimen(s)

10 X 10 um (minimum 5 x 10 um) unstained sections of formalin-fixed paraffin-embedded tissue and 1 x 4 um (minimum 1 x 5 um) section with H & E staining, ≥20% tumor content (minimum ≥10% tumor content) • Formalin-fixed paraffin-embedded FNA • 50 uL of 20 ng/uL (minimum 10 uL of 10 ng/uL) extracted DNA

Minimum Volume

10 mm2, ≥10% tumor content

Collection Instructions

For FFPE and slides a pathology report must be submitted with sample. Do not reject.

Transport Container

Formalin-fixed paraffin-embedded tissue block

Transport Temperature

Room temperature

Specimen Stability

  • Tumor tissue
  • Room temperature: 5 years
  • Refrigerated: 5 years
  • Frozen: Unacceptable
  •  
  • Unstained sections of FFPE tissue and H & E stained section
  • Room temperature: 28 days
  • Refrigerated: 5 years
  • Frozen: Unacceptable
  •  
  • FFPE FNA
  • Room temperature: 5 years
  • Refrigerated: 5 years
  • Frozen: Unacceptable
  •  
  • Extracted DNA
  • Room temperature: 14 days
  • Refrigerated: 90 days
  • Frozen: 5 years
  •  

Reject Criteria

Sample with <10% tumor content • Sample less than minimal requirements

Setup Schedule

Service Area must be determined
200 mm2, ≥20% tumor content of tumor tissue collected in a formalin-fixed, paraffin-embedded tissue
10 X 10 um (minimum 5 x 10 um) unstained sections of formalin-fixed paraffin-embedded tissue and 1 x 4 um (minimum 1 x 5 um) section with H & E staining, ≥20% tumor content (minimum ≥10% tumor content) • Formalin-fixed paraffin-embedded FNA • 50 uL of 20 ng/uL (minimum 10 uL of 10 ng/uL) extracted DNA
10 mm2, ≥10% tumor content
For FFPE and slides a pathology report must be submitted with sample. Do not reject.
Formalin-fixed paraffin-embedded tissue block
Room temperature
Tumor tissue
Room temperature: 5 years
Refrigerated: 5 years
Frozen: Unacceptable

Unstained sections of FFPE tissue and H & E stained section
Room temperature: 28 days
Refrigerated: 5 years
Frozen: Unacceptable

FFPE FNA
Room temperature: 5 years
Refrigerated: 5 years
Frozen: Unacceptable

Extracted DNA
Room temperature: 14 days
Refrigerated: 90 days
Frozen: 5 years
Sample with <10% tumor content • Sample less than minimal requirements
Service Area must be determined
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection is not available in your area through Quest Mobile.
Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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