FISH, Myeloid Neoplasms, MECOM (EVI1), 3q26.2

Test Code

91391

CPT Code(s)

88271 (x3), 88275

CPT Code is subject to a Medicare Limited Coverage Policy and may require a signed ABN when ordering.

Test Code

91391

CPT Code(s)

88271 (x3), 88275

CPT Code is subject to a Medicare Limited Coverage Policy and may require a signed ABN when ordering.

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.

In-home collection is not available in your area through Quest Mobile.

Clinical Significance

FISH, Myeloid Neoplasms, MECOM (EVI1), 3q26.2 - Disruption of the human entropic virus integration site (EVI1 or MECOM) gene located at chromosome band 3q26.2 is associated with myeloid neoplasms and is indicative of a poor prognosis. EVI1 rearrangements are especially frequent in myeloid blast crisis that evolves through tyrosine kinase inhibitors. It has been associated with dysplasia of megakaryocytes and alters differentiation of other myeloid cells. Associated rearrangements include inv(3)(q21q26), t(3;3)q21;q26), t(3;21)(q26;q22) and t(3;12)(q26;p13).

Test Resources

None found for this test
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Test Details

Methodology

Fluorescence in situ Hybridization (FISH)

Assay Category

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

See Laboratory Report

Alternative Name(s)

Ecotropic Viral Integration Site 1 (EVI1),MDS1 and EVI1 Complex Locus

LOINC® Codes, Performing Laboratory

Service Area must be determined

Methodology

Fluorescence in situ Hybridization (FISH)

Assay Category

Reference Range(s)

See Laboratory Report

Alternative Name(s)

Ecotropic Viral Integration Site 1 (EVI1),MDS1 and EVI1 Complex Locus

LOINC® Codes, Performing Laboratory

Service Area must be determined

Preferred Specimen(s)

3 mL bone marrow or 5 mL whole blood collected in a sodium heparin (green-top) tube

Alternative Specimen(s)

Bone marrow or whole blood collected in: Sodium heparin (royal blue-top) tube or sodium heparin lead-free (tan-top) tube

Minimum Volume

1 mL bone marrow • 3 mL whole blood

Transport Container

Sodium heparin (green-top) tube

Transport Temperature

Room temperature

Specimen Stability

Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.

Setup Schedule

Service Area must be determined

Preferred Specimen(s)

3 mL bone marrow or 5 mL whole blood collected in a sodium heparin (green-top) tube

Alternative Specimen(s)

Bone marrow or whole blood collected in: Sodium heparin (royal blue-top) tube or sodium heparin lead-free (tan-top) tube

Minimum Volume

1 mL bone marrow • 3 mL whole blood

Transport Container

Sodium heparin (green-top) tube

Transport Temperature

Room temperature

Specimen Stability

Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.

Setup Schedule

Service Area must be determined

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.

In-home collection is not available in your area through Quest Mobile.

Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

The tests listed by specialty and category are a select group of tests offered. For a complete list of Quest Diagnostics tests, please adjust the filter options chosen, or refer to our Directory of Services.