Automated Pap with Age-Based Screening Protocols

Automated Pap with Age-Based Screening Protocols

Test Code

91384
88175*
*see below for age related testing and CPT codes
91384
88175*
*see below for age related testing and CPT codes
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano | Quest Nichols Institute -San Juan Capistrano, CA. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection is not available in your area through Quest Mobile.

Clinical Significance

Automated Pap with Age-Based Screening Protocols - This new test code is designed to help clinicians order age-appropriate testing for cervical cancer screening and STIs. Based on the patient's age and on ACOG Practice Guidelines for cervical cancer screening and Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) screening, testing in addition to the Pap will be processed as follows:

• Patients aged 21-24: Patients will receive Image-guided Pap and, when the result is ASC-US, a high-risk HPV mRNA test will be performed. Additionally, testing for CT/NG will be performed.
• ...

Test Resources

None found for this test
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Test Details

Includes

  • Patients aged 21-24: If the Pap result is ASC-US then the HPV mRNA assay will be performed at an additional charge (CPT code(s): 87624). Chlamydia trachomatis (CT)/Neisseria gonorrhoeae (NG) RNA, TMA will also be performed (CPT code(s): 87491, 87591).
  •  
  • Patients aged 25-29: If the Pap result is ASC-US then the HPV mRNA assay will be performed at an additional charge (CPT code(s): 87624).
  •  
  • Patients aged 30-65: If the Pap result is negative and the HPV mRNA screen (CPT code(s): 87624) is positive (detected), then HPV mRNA Genotypes 16, 18/45 will be performed at an additional charge (CPT code(s): 87625).
  •  
  • Pap results requiring physician interpretation will be performed at an additional charge (CPT Code(s): 88141; HCPCS: G0124).

Methodology

Pap: Microscopy with Computer-imaging
HPV/CT/NG: Transcription Mediated Amplification (TMA)

Assay Category

The analytical performance characteristics of this assay, when used to test SurePath™ specimens have been determined by Quest Diagnostics.

Alternative Name(s)

Age Based Pap Screening Protocol,Cervical Cancer Screening Protocol, Age-Based,Age Based Smart Codes Pap Screening,Smart Codes for Age Based Pap Screen

LOINC® Codes, Performing Laboratory

Service Area must be determined
Patients aged 21-24: If the Pap result is ASC-US then the HPV mRNA assay will be performed at an additional charge (CPT code(s): 87624). Chlamydia trachomatis (CT)/Neisseria gonorrhoeae (NG) RNA, TMA will also be performed (CPT code(s): 87491, 87591).

Patients aged 25-29: If the Pap result is ASC-US then the HPV mRNA assay will be performed at an additional charge (CPT code(s): 87624).

Patients aged 30-65: If the Pap result is negative and the HPV mRNA screen (CPT code(s): 87624) is positive (detected), then HPV mRNA Genotypes 16, 18/45 will be performed at an additional charge (CPT code(s): 87625).

Pap results requiring physician interpretation will be performed at an additional charge (CPT Code(s): 88141; HCPCS: G0124).

Methodology

Pap: Microscopy with Computer-imaging
HPV/CT/NG: Transcription Mediated Amplification (TMA)
The analytical performance characteristics of this assay, when used to test SurePath™ specimens have been determined by Quest Diagnostics.

Alternative Name(s)

Age Based Pap Screening Protocol,Cervical Cancer Screening Protocol, Age-Based,Age Based Smart Codes Pap Screening,Smart Codes for Age Based Pap Screen
Service Area must be determined

Preferred Specimen(s)

Pap sample collected in 1 ThinPrep® pap vial or pap sample collected in 1 SurePath™ pap vial

Minimum Volume

1 ThinPrep pap vial • 1 SurePath pap vial

Collection Instructions

For instructions refer to
//www.questdiagnostics.com/dms/Documents/Other/Specimen_Collection_and_Transport_Guide_2019.pdf

Transport Container

1 ThinPrep pap vial or 1 SurePath pap vial

Transport Temperature

Room temperature

Specimen Stability

  • SurePath Pap - SurePath Pap Vial
  • Room Temperature: 28 days
  • Refrigerated: 6 months
  • Frozen: Unacceptable
  •  
  • SurePath HPV - SurePath Pap Vial
  • Room temperature: 7 days
  • Refrigerated: 7 days
  • Frozen: Unacceptable
  •  
  • SurePath HPV - SurePath Preservative Fluid in Aptima® Transfer Tube
  • Room temperature: 7 days
  • Refrigerated: 7 days
  • Frozen: Unacceptable
  •  
  • SurePath CT/NG - SurePath Pap Vial
  • Room temperature: 4 days
  • Refrigerated: Unacceptable
  • Frozen: Unacceptable
  •  
  • SurePath CT/NG - SurePath Preservative Fluid in Aptima® Transfer Tube
  • Room temperature: 14 days
  • Refrigerated: 14 days
  • Frozen: Unacceptable
  •  
  • ThinPrep Pap
  • Room temperature: 42 days
  • Refrigerated: Unacceptable
  • Frozen: Unacceptable
  •  
  • HPV - ThinPrep Pap Vial
  • Room temperature: 30 days
  • Refrigerated: 105 days
  • Frozen: Unacceptable
  •  
  • ThinPrep Pap Vial in Aptima® Transfer Tube
  • Room temperature: 60 days
  • Refrigerated: 60 days
  • Frozen: 2 years
  •  
  • CT/NG - ThinPrep Pap Vial
  • Room temperature: 30 days
  • Refrigerated: 30 days
  • Frozen: Unacceptable
  •  
  • CT/NG - ThinPrep Pap Vial in Aptima® Transfer Tube
  • Room temperature: 14 days
  • Refrigerated: 30 days
  • Frozen: 1 year
  •  
  • Refer to local service area for specimen retention.

Reject Criteria

ThinPrep vials received refrigerated or frozen • Swabs • Cervical swabs in Digene® HC cervical sampler • Digene® vials • SurePath vials without the head of the collection device(s) in the fluid • SurePath vials received frozen

Setup Schedule

Service Area must be determined
Pap sample collected in 1 ThinPrep® pap vial or pap sample collected in 1 SurePath™ pap vial
1 ThinPrep pap vial • 1 SurePath pap vial
For instructions refer to
//www.questdiagnostics.com/dms/Documents/Other/Specimen_Collection_and_Transport_Guide_2019.pdf
1 ThinPrep pap vial or 1 SurePath pap vial
Room temperature
SurePath Pap - SurePath Pap Vial
Room Temperature: 28 days
Refrigerated: 6 months
Frozen: Unacceptable

SurePath HPV - SurePath Pap Vial
Room temperature: 7 days
Refrigerated: 7 days
Frozen: Unacceptable

SurePath HPV - SurePath Preservative Fluid in Aptima® Transfer Tube
Room temperature: 7 days
Refrigerated: 7 days
Frozen: Unacceptable

SurePath CT/NG - SurePath Pap Vial
Room temperature: 4 days
Refrigerated: Unacceptable
Frozen: Unacceptable

SurePath CT/NG - SurePath Preservative Fluid in Aptima® Transfer Tube
Room temperature: 14 days
Refrigerated: 14 days
Frozen: Unacceptable

ThinPrep Pap
Room temperature: 42 days
Refrigerated: Unacceptable
Frozen: Unacceptable

HPV - ThinPrep Pap Vial
Room temperature: 30 days
Refrigerated: 105 days
Frozen: Unacceptable

ThinPrep Pap Vial in Aptima® Transfer Tube
Room temperature: 60 days
Refrigerated: 60 days
Frozen: 2 years

CT/NG - ThinPrep Pap Vial
Room temperature: 30 days
Refrigerated: 30 days
Frozen: Unacceptable

CT/NG - ThinPrep Pap Vial in Aptima® Transfer Tube
Room temperature: 14 days
Refrigerated: 30 days
Frozen: 1 year

Refer to local service area for specimen retention.
ThinPrep vials received refrigerated or frozen • Swabs • Cervical swabs in Digene® HC cervical sampler • Digene® vials • SurePath vials without the head of the collection device(s) in the fluid • SurePath vials received frozen
Service Area must be determined
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano | Quest Nichols Institute -San Juan Capistrano, CA. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection is not available in your area through Quest Mobile.
Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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