FISH, MET Amplification
Test code
CPT code(s)*
Test resources
Test FAQ
Details
Methodology
Fluorescence in situ Hybridization (FISH)
Assay category
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Alternative name(s)
Renal Cancer,
Tyrosine Kinase
,c-MET,NSCLC,Mesencymal Epithelial Transition Factor,7q31,Hepatocyte Growth Factor Receptor,Kidney Cancer Specimen requirements | |
|---|---|
| Patient preparation | None Specified |
| Preferred specimen(s) | Formalin-fixed, paraffin-embedded tissue |
| Alternative specimen(s) | 5x5 mm tumor tissue collected in culture transport medium • 4-5 microns sections on charged slides (x5) |
| Minimum volume | Tumor biopsy: 5x5 mm |
| Collection instructions | Acceptable samples: For MET determination in solid tumors, only biopsies with histologically proven tumor involvement should be tested. Samples that can be tested include tumor biopsy in tissue culture media, formalin-fixed, paraffin-embedded block, or a minimum of 4 charged/+slides from formalin-fixed, paraffin-embedded tissue. Specimen must be fixed in 10% neutral buffered formalin. Fixation between 6 and 48 hours is recommended. Pathology report must accompany paraffin block or slides. |
| Transport container | Formalin-fixed, paraffin-embedded tissue block |
| Transport temperature | Room temperature |
| Specimen stability | Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject. |
| Reject criteria | Whole blood • Bone marrow |
Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.
*The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.
This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.
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