Human Transforming Growth Factor beta 1 (TGF-b1)

Human Transforming Growth Factor beta 1 (TGF-b1)

Test Code

91238
83520
91238
83520
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection is not available in your area through Quest Mobile.

Clinical Significance

Human Transforming Growth Factor beta 1 (TGF-b1) - Transforming Growth Factor (TGF) plays a crucial role in tissue regeneration, cell differentiation, embryonic development, and regulation of the immune system. Transforming growth factor beta is found in hematopoietic (blood-forming) tissue and initiates a signaling pathway that suppresses the early development of cancer cells. It enhances the deposition of extracellular matrix and may play potential role in wound healing and cirrhosis formation. Many cells synthesize TGF-b and almost all of them have specific receptors for this peptide.

Test Resources

None found for this test
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Test Details

Methodology

Enzyme Linked Immunosorbent Assay (ELISA)

Assay Category

The performance characteristics of the listed assay was validated by BioAgilytix Diagnostics. The US FDA has not approved or cleared this test. The results of this assay can be used for clinical diagnosis without FDA approval. BioAgilytix Diagnostics is a CLIA certified, CAP accredited laboratory for performing high complexity assays such as this one.

Reference Range(s)

0-22062 pg/mL

LOINC® Codes, Performing Laboratory

Service Area must be determined

Methodology

Enzyme Linked Immunosorbent Assay (ELISA)
The performance characteristics of the listed assay was validated by BioAgilytix Diagnostics. The US FDA has not approved or cleared this test. The results of this assay can be used for clinical diagnosis without FDA approval. BioAgilytix Diagnostics is a CLIA certified, CAP accredited laboratory for performing high complexity assays such as this one.

Reference Range(s)

0-22062 pg/mL
Service Area must be determined

Preferred Specimen(s)

1 mL platelet-free plasma collected in EDTA (lavender-top) tube

Minimum Volume

0.25 mL

Collection Instructions

PSC Collections: Collect in EDTA (lavender-top) tube and immediately centrifuge to prepare platelet-poor plasma. Decant the plasma into another pour-over tube. Centrifuge a second time and pour over plasma. Freeze immediately.

Client Collections: Collect in EDTA (lavender-top) tube. Centrifuge for 15 minutes at 1000 X g within 30 minutes of collection. Centrifuge plasma again at 3000 X g for 10 minutes for complete platelet removal. Freeze Immediately.

For fixed speed centrifuges such as 645e: Collect in EDTA (lavender-top) tube. Centrifuge 3 times for 10 minutes at 1600 X g while decanting the plasma each time before the next spin within 30 minutes of collection. Freeze immediately.

Transport Container

Transport tube

Transport Temperature

Frozen

Specimen Stability

  • Room temperature: Not established
  • Refrigerated: 48 hours
  • Frozen -20° C: 14 days
  • Frozen -70° C: 30 days

Reject Criteria

Hemolysis • Grossly lipemic • Specimens with particulate matter or microbial contamination • Specimens outside of listed stability • Samples submitted without two unique identifiers and date of collection

Setup Schedule

Service Area must be determined
1 mL platelet-free plasma collected in EDTA (lavender-top) tube
0.25 mL
PSC Collections: Collect in EDTA (lavender-top) tube and immediately centrifuge to prepare platelet-poor plasma. Decant the plasma into another pour-over tube. Centrifuge a second time and pour over plasma. Freeze immediately.

Client Collections: Collect in EDTA (lavender-top) tube. Centrifuge for 15 minutes at 1000 X g within 30 minutes of collection. Centrifuge plasma again at 3000 X g for 10 minutes for complete platelet removal. Freeze Immediately.

For fixed speed centrifuges such as 645e: Collect in EDTA (lavender-top) tube. Centrifuge 3 times for 10 minutes at 1600 X g while decanting the plasma each time before the next spin within 30 minutes of collection. Freeze immediately.
Transport tube
Frozen
Room temperature: Not established
Refrigerated: 48 hours
Frozen -20° C: 14 days
Frozen -70° C: 30 days
Hemolysis • Grossly lipemic • Specimens with particulate matter or microbial contamination • Specimens outside of listed stability • Samples submitted without two unique identifiers and date of collection
Service Area must be determined
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection is not available in your area through Quest Mobile.
Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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