ROMA™ (Risk of Ovarian Malignancy Algorithm)

ROMA™ (Risk of Ovarian Malignancy Algorithm)

Test Code

91155
81500
91155
81500
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection is not available in your area through Quest Mobile.

Clinical Significance

ROMA™ (Risk of Ovarian Malignancy Algorithm) - The risk of Ovarian Malignancy Algorithm (ROMA™) test is intended to aid in assessing the risk of ovarian cancer in women with a pelvic mass based on the patient's HE4 and CA125 levels, and their menopausal status. Women with ROMA™ levels above the cutoff have an increased risk of ovarian cancer. ROMA™ must be interpreted in conjunction with an independent clinical and radiological assessment.

The ROMA™ test is indicated for women who meet the following criteria:
over age 18; presence of an ovarian pelvic mass for which surgery is planned; and not yet ...

Test Resources

None found for this test
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Test Details

Includes

  • CA125, HE4 Ovarian CA Monitoring, and Risk of Ovarian Malignancy calculation

Methodology

Calculation (CALC) • Chemiluminescent Microparticle Immunoassay (CMIA)

Reference Range(s)

ROMA Premenopausal <1.31
ROMA Postmenopausal <2.77
CA125 <35 U/mL
HE4, Ovarian CA Monitoring  
  Female Premenopausal ≤70 pmol/L
  Female Postmenopausal ≤140 pmol/L

LOINC® Codes, Performing Laboratory

Service Area must be determined
CA125, HE4 Ovarian CA Monitoring, and Risk of Ovarian Malignancy calculation

Methodology

Calculation (CALC) • Chemiluminescent Microparticle Immunoassay (CMIA)

Reference Range(s)

ROMA Premenopausal <1.31
ROMA Postmenopausal <2.77
CA125 <35 U/mL
HE4, Ovarian CA Monitoring  
  Female Premenopausal ≤70 pmol/L
  Female Postmenopausal ≤140 pmol/L
Service Area must be determined

Preferred Specimen(s)

1 mL serum

Minimum Volume

0.5 mL

Collection Instructions

Sample collected in red-top tube must be allowed to clot for at least 30 minutes but no longer than 1 hour.

Transport Container

Transport tube

Transport Temperature

Frozen

Specimen Stability

  • Room temperature: 24 hours
  • Refrigerated: 72 hours
  • Frozen: 28 days

Reject Criteria

Moderate to gross hemolysis • Lipemia • Icteric specimens • Presence of fibrin • Red blood cells • Other particulate matter • Obvious microbial contamination

Setup Schedule

Service Area must be determined
1 mL serum
0.5 mL
Sample collected in red-top tube must be allowed to clot for at least 30 minutes but no longer than 1 hour.
Transport tube
Frozen
Room temperature: 24 hours
Refrigerated: 72 hours
Frozen: 28 days
Moderate to gross hemolysis • Lipemia • Icteric specimens • Presence of fibrin • Red blood cells • Other particulate matter • Obvious microbial contamination
Service Area must be determined
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection is not available in your area through Quest Mobile.
Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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