Chlordiazepoxide and Metabolites

Test Code

91123

CPT Code(s)

80299

CPT Code is subject to a Medicare Limited Coverage Policy and may require a signed ABN when ordering.

Test Code

91123

CPT Code(s)

80299

CPT Code is subject to a Medicare Limited Coverage Policy and may require a signed ABN when ordering.

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.

In-home collection is not available in your area through Quest Mobile.

Clinical Significance

Chlordiazepoxide and Metabolites -

This definitive drug assay is used to measure concentrations of chlordiazepoxide, norchlordiazepoxide, and nordiazepam in serum. This therapeutic drug monitoring assay may be used to assess if chlordiazepoxide and metabolites are within therapeutic range. Urine and oral fluid are the specimens of choice for routine monitoring of patients taking prescription drugs.

Chlordiazepoxide is a long-acting benzodiazepine used to treat adults for anxiety disorder, preoperative apprehension and anxiety, and withdrawal symptoms of acute alcohol use disorder. It is also used to treat children older ...

Test Resources

Topic Brief

Drug Half-Life, Steady State, and Recommended Sample Collection Time

Test Details

Includes

Chlordiazepoxide, Norchlordiazepoxide, Nordiazepam

Patient Preparation

Collect at trough concentration, i.e., just before the administration of the next dose.

Methodology

Chromatography/Mass Spectrometry

Assay Category

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

Chlordiazepoxide	100-3000 ng/mL
Norchlordiazepoxide	100-3000 ng/mL
Nordiazepam	100-1500 ng/mL

LOINC® Codes, Performing Laboratory

Service Area must be determined

Includes

Chlordiazepoxide, Norchlordiazepoxide, Nordiazepam

Patient Preparation

Collect at trough concentration, i.e., just before the administration of the next dose.

Methodology

Chromatography/Mass Spectrometry

Assay Category

Reference Range(s)

Chlordiazepoxide	100-3000 ng/mL
Norchlordiazepoxide	100-3000 ng/mL
Nordiazepam	100-1500 ng/mL

LOINC® Codes, Performing Laboratory

Service Area must be determined

Preferred Specimen(s)

2 mL serum collected in a red top tube (no gel)

Minimum Volume

1 mL

Collection Instructions

Serum separator tubes (SST) are not acceptable; use polyrpopylene tubes and ship on cold pack by overnight courier.

Transport Container

Transport tube

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: Unacceptable
Refrigerated: 5 days
Frozen: 14 days

Reject Criteria

Received room temperature • Serum separator tube (SST)

Setup Schedule

Service Area must be determined

Preferred Specimen(s)

2 mL serum collected in a red top tube (no gel)

Minimum Volume

1 mL

Collection Instructions

Serum separator tubes (SST) are not acceptable; use polyrpopylene tubes and ship on cold pack by overnight courier.

Transport Container

Transport tube

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: Unacceptable
Refrigerated: 5 days
Frozen: 14 days

Reject Criteria

Received room temperature • Serum separator tube (SST)

Setup Schedule

Service Area must be determined

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.

In-home collection is not available in your area through Quest Mobile.

Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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