Nicotine and Expanded Metabolites, LC/MS/MS, Urine

Nicotine and Expanded Metabolites, LC/MS/MS, Urine

Test Code

90982
80323 (HCPCS: G0480)
CPT Code is subject to a Medicare Limited Coverage Policy and may require a signed ABN when ordering.
90982
80323 (HCPCS: G0480)
CPT Code is subject to a Medicare Limited Coverage Policy and may require a signed ABN when ordering.
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano | Quest Nichols Institute -San Juan Capistrano, CA. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection may be available in your area for purchase through Quest Mobile.

Clinical Significance

Nicotine and Expanded Metabolites, LC/MS/MS, Urine - This assay is used for the detection of nicotine and several metabolites and the related alkaloid anabasine in urine to determine the tobacco exposure status of the individual. Nicotine has a short half-life of approximately sixty minutes; Its presence may indicate recent tobacco exposure. The half-life of the various nicotine metabolites is longer and provides a larger window of detection for tobacco exposure. The presence of anabasine is indicative of tobacco exposure (smoked or smokeless) versus the use of a nicotine replacement patch product. Anabasine is a related alkaloid found only in the ...

Test Resources

None found for this test
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Test Details

Includes

  • Nicotine, Cotinine, 3-OH-Cotinine, Nornicotine, Norcotinine, Anabasine

Methodology

Chromatography/Mass Spectrometry

Assay Category

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

Non-Smoker 
(ng/mL)		Active Tobacco User 
(ng/mL)
Nicotine<17200-700
Cotinine<20300-1300
3-OH-Cotinine<503000-25000
Nornicotine<230-900
Norcotinine<2Not established
Anabasine<210-500

Alternative Name(s)

Anabasine

LOINC® Codes, Performing Laboratory

Service Area must be determined
Nicotine, Cotinine, 3-OH-Cotinine, Nornicotine, Norcotinine, Anabasine

Methodology

Chromatography/Mass Spectrometry
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

Non-Smoker 
(ng/mL)		Active Tobacco User 
(ng/mL)
Nicotine<17200-700
Cotinine<20300-1300
3-OH-Cotinine<503000-25000
Nornicotine<230-900
Norcotinine<2Not established
Anabasine<210-500

Alternative Name(s)

Anabasine
Service Area must be determined

Preferred Specimen(s)

1 mL random urine

Minimum Volume

0.5 mL

Transport Container

Plastic urine container

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

  • Room temperature: 72 hours
  • Refrigerated: 14 days
  • Frozen: 30 days

Setup Schedule

Service Area must be determined
1 mL random urine
0.5 mL
Plastic urine container
Refrigerated (cold packs)
Room temperature: 72 hours
Refrigerated: 14 days
Frozen: 30 days
Service Area must be determined
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano | Quest Nichols Institute -San Juan Capistrano, CA. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection may be available in your area for purchase through Quest Mobile.
Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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