Fibrinolysis Comprehensive Panel

Test code

90923

CPT code(s)*

85360, 85362 (x2), 85379, 85410, 85415 (x2), 85420

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide Service Area Information to find available tests you can order.

In-home collection is not available in your area through Quest Mobile.

Clinical significance

Fibrinolysis Comprehensive Panel - An increase in PAI-1 antigen is associated with an increased risk for post-operative venous thrombosis, myocardial infarction, and (probably) stroke. A severe deficiency of alpha-2 antiplasmin or PAI-1 antigen has been associated with bleeding. A shortened euglobulin lysis time correlates with a severe deficiency of alpha-2 antiplasmin or PAI-1 antigen. Elevations in fibrin monomer, fibrinogen degradation products, and D-dimer usually indicate vascular thrombosis (mainly venous) but are also associated with malignancy and infection. Conversely, a normal D-dimer and/or negative fibrin monomer suggests the absence of deep venous thrombosis…

Test resources

None found for this test
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Details

Test details

Includes

Alpha-2-Antiplasmin
D-Dimer, Quantitative
Euglobulin Clot Lysis Time
Fibrinogen Degradation Products (FDP)
Plasminogen Activator Inhibitor (PAI-1) Ag
Plasminogen Activity
Tissue Plasminogen Activator (TPA), EIA
Fibrin Monomer

Methodology

Chromogenic Assay • Clot Dissolution • Hemagglutination (HA) • Immunoassay (IA) • Latex Agglutination (LA)

Specimen requirements
Patient preparation	Morning fasting is required. Since lipemia may interfere with clotting endpoint detection, a two-hour fast is recommended.
Preferred specimen(s)	1 mL frozen, platelet-poor plasma collected in each of five separate 3.2% sodium citrate (light blue-top) tubes
Minimum volume	0.8 mL (x5)
Collection instructions	Please submit a separate, frozen vial for each special coagulation assay ordered. Draw blood in a light blue-top tube containing 3.2% sodium citrate, mix gently by inverting 3-4 times. Centrifuge 15 minutes at 1500 g within one hour of collection. Using a plastic pipette, remove plasma, taking care to avoid the WBC/platelet buffy layer and place into a plastic vial. Centrifuge a second time and transfer platelet-poor plasma into a new plastic vial(s). Freeze immediately and transport on dry ice. To avoid release of plasminogen activator, do not massage vein vigorously, pump fist excessively or leave tourniquet in place for a prolonged period. Centrifuge within 30 minutes after collection to get platelet-poor plasma and freeze on dry ice. Prohibit exercise prior to drawing sample.
Transport container	Transport tubes (x5)
Transport temperature	Frozen
Specimen stability	Room temperature: Unacceptable Refrigerated: Unacceptable Frozen: 14 days
Reject criteria	Gross hemolysis • Grossly lipemic • Grossly icteric

Reference range(s)

See Laboratory Report

LOINC® codes

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Service Area Information

Performing lab & setup schedule

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Service Area Information

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

*The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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