Cardio IQ® CYP2C19 Genotype

Test Code

90668

CPT Code(s)

81225

CPT Code is subject to a Medicare Limited Coverage Policy and may require a signed ABN when ordering.

Test Code

90668

CPT Code(s)

81225

CPT Code is subject to a Medicare Limited Coverage Policy and may require a signed ABN when ordering.

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.

In-home collection is not available in your area through Quest Mobile.

Clinical Significance

Cardio IQ® CYP2C19 Genotype - This pharmacogenetic test may be used to help guide clopidogrel prescribing, especially in patients with acute coronary syndrome (ACS) who have undergone percutaneous coronary intervention (PCI) [1]. This test detects common variants in the CYP2C19 gene, the most validated genetic determinant of clopidogrel response.

Clopidogrel is a prodrug that needs to be metabolized to its active form by cytochrome P450 2C19 (CYP2C19). Patients who carry a no-function allele of CYP2C19 have reduced clopidogrel activation, reduced platelet inhibition, and higher risk of major adverse cardiovascular ...

Test Resources

None found for this test
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Test Details

Methodology

Allele-Specific Primer Extension • Polymerase Chain Reaction (PCR)

Assay Category

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

See Laboratory Report

Alternative Name(s)

CardioIQ®,CYP2C19 Genotype

LOINC® Codes, Performing Laboratory

Service Area must be determined

Methodology

Allele-Specific Primer Extension • Polymerase Chain Reaction (PCR)

Assay Category

Reference Range(s)

See Laboratory Report

Alternative Name(s)

CardioIQ®,CYP2C19 Genotype

LOINC® Codes, Performing Laboratory

Service Area must be determined

Preferred Specimen(s)

4 mL whole blood collected in an EDTA (lavender-top) tube

Minimum Volume

2 mL

Collection Instructions

Multiple (up to 8) cardiovascular-related genetic tests can be performed on a single specimen. A second EDTA (lavender- top) tube is required if non-genetic tests are simultaneously ordered that require an EDTA (lavender-top) tube. For whole blood samples, follow normal phlebotomy procedures.

Transport Container

EDTA (lavender-top)

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: 8 days
Refrigerated: 8 days
Frozen: 30 days

Setup Schedule

Service Area must be determined

Preferred Specimen(s)

4 mL whole blood collected in an EDTA (lavender-top) tube

Minimum Volume

2 mL

Collection Instructions

Transport Container

EDTA (lavender-top)

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: 8 days
Refrigerated: 8 days
Frozen: 30 days

Setup Schedule

Service Area must be determined

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.

In-home collection is not available in your area through Quest Mobile.

Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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