Nicotine and Cotinine, Urine

Test Code

90646

CPT Code(s)

80323 (HCPCS: G0480)

CPT Code is subject to a Medicare Limited Coverage Policy and may require a signed ABN when ordering.

Test Code

90646

CPT Code(s)

80323 (HCPCS: G0480)

CPT Code is subject to a Medicare Limited Coverage Policy and may require a signed ABN when ordering.

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.

In-home collection may be available in your area for purchase through Quest Mobile.

Clinical Significance

Nicotine and Cotinine, Urine - This assay is used for the detection of nicotine and cotinine in urine to determine the tobacco exposure status of the individual. Nicotine has a short half-life of approximately forty minutes; its presence may indicate recent tobacco exposure. Cotinine, the major nicotine metabolite, has a half-life of 24 hours and is detectable for several days after cessation of tobacco exposure.

Test Resources

None found for this test
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Test Details

Methodology

Chromatography/Mass Spectrometry

Assay Category

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

Nicotine, Urine

Smoker	200-700 ng/mL
Nonsmoker	≤17 ng/mL

Cotinine, Urine

Smoker	300-1300 ng/mL
Nonsmoker	≤20 ng/mL

LOINC® Codes, Performing Laboratory

Service Area must be determined

Methodology

Chromatography/Mass Spectrometry

Assay Category

Reference Range(s)

Nicotine, Urine

Smoker	200-700 ng/mL
Nonsmoker	≤17 ng/mL

Cotinine, Urine

Smoker	300-1300 ng/mL
Nonsmoker	≤20 ng/mL

LOINC® Codes, Performing Laboratory

Service Area must be determined

Preferred Specimen(s)

1 mL random urine

Minimum Volume

0.5 mL

Transport Container

Plastic urine container

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: 72 hours
Refrigerated: 14 days
Frozen: 30 days

Setup Schedule

Service Area must be determined

Preferred Specimen(s)

1 mL random urine

Minimum Volume

0.5 mL

Transport Container

Plastic urine container

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: 72 hours
Refrigerated: 14 days
Frozen: 30 days

Setup Schedule

Service Area must be determined

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.

In-home collection may be available in your area for purchase through Quest Mobile.

Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

The tests listed by specialty and category are a select group of tests offered. For a complete list of Quest Diagnostics tests, please adjust the filter options chosen, or refer to our Directory of Services.