FISH, FGFR1, 8p11-12

Test code

90517

CPT code(s)*

88271 (x2), 88275

**CPT Code is subject to a Medicare Limited Coverage Policy and may require a signed ABN when ordering.

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide Service Area Information to find available tests you can order.

In-home collection is not available in your area through Quest Mobile.

Clinical significance

FISH, FGFR1, 8p11-12 - FISH testing with the FGFR1 probe allows detection of translocations involving FGFR1 and another chromosome region (usually a tyrosine kinase coding gene). Fusion of FGFR1 with a tyrosine kinase coding gene leads to kinase activation.

Test resources

None found for this test
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Details

Test details

Methodology

Fluorescence in situ Hybridization (FISH)

Assay category

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Specimen requirements
Patient preparation	None Specified
Preferred specimen(s)	3 mL bone marrow or 5 mL whole blood collected in a sodium heparin (green-top) tube
Alternative specimen(s)	Bone marrow collected in: Transport medium, sodium heparin (royal blue-top) tube or sodium heparin lead free (tan-top) tube • Whole blood collected in: Sodium heparin (royal blue-top) tube or sodium heparin lead free (tan-top) tube • 5x5 mm fresh tumor tissue in transport medium • 5x5 mm tumor tissue in formalin-fixed, paraffin-embedded tissue block
Minimum volume	1 mL bone marrow • 3 mL whole blood
Transport container	Sodium heparin (green-top) tube
Transport temperature	Room temperature
Specimen stability	Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.

Reference range(s)

See Laboratory Report

LOINC® codes

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Service Area Information

Performing lab & setup schedule

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Service Area Information

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

*The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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