FISH, T-cell Receptor alpha/delta, 14q11.2

Test Code

90513

CPT Code(s)

88271 (x2), 88275

CPT Code is subject to a Medicare Limited Coverage Policy and may require a signed ABN when ordering.

Test Code

90513

CPT Code(s)

88271 (x2), 88275

CPT Code is subject to a Medicare Limited Coverage Policy and may require a signed ABN when ordering.

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.

In-home collection is not available in your area through Quest Mobile.

Clinical Significance

FISH, T-cell Receptor alpha/delta, 14q11.2 - Rearrangements of the T-cell receptor alpha/delta TRA/D are recurrent in both mature and immature T-cell neoplasms. Many of these TRA/D rearrangements are cryptic at the conventional cytogenetic level and therefore are detected mainly by molecular testing and FISH. The majority of these rearrangements are translocations that juxtapose a transcription factor gene to the TRA/D locus leading to its aberrant expression in developing thymocytes.

Test Resources

None found for this test
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Test Details

Methodology

Fluorescence in situ Hybridization (FISH)

Assay Category

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

LOINC® Codes, Performing Laboratory

Service Area must be determined

Methodology

Fluorescence in situ Hybridization (FISH)

Assay Category

LOINC® Codes, Performing Laboratory

Service Area must be determined

Preferred Specimen(s)

3 mL bone marrow or 5 mL whole blood collected in a sodium heparin (green-top) tube

Alternative Specimen(s)

Bone marrow collected in: Transport medium, sodium heparin (royal blue-top) tube, or sodium heparin lead-free (tan-top) tube • Whole blood collected in: Sodium heparin (royal blue-top) tube or sodium heparin lead-free (tan-top) tube • 5x5 mm tumor tissue in formalin-fixed, paraffin-embedded tissue block

Minimum Volume

1 mL bone marrow • 3 mL whole blood

Transport Container

Sodium heparin (green-top) tube

Transport Temperature

Room temperature

Specimen Stability

Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.

Setup Schedule

Service Area must be determined

Preferred Specimen(s)

3 mL bone marrow or 5 mL whole blood collected in a sodium heparin (green-top) tube

Alternative Specimen(s)

Minimum Volume

1 mL bone marrow • 3 mL whole blood

Transport Container

Sodium heparin (green-top) tube

Transport Temperature

Room temperature

Specimen Stability

Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.

Setup Schedule

Service Area must be determined

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.

In-home collection is not available in your area through Quest Mobile.

Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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