RET/PTC Rearrangement, Thyroid Cancer

RET/PTC Rearrangement, Thyroid Cancer

Test Code

90473
81479
CPT Code is subject to a Medicare Limited Coverage Policy and may require a signed ABN when ordering.
90473
81479
CPT Code is subject to a Medicare Limited Coverage Policy and may require a signed ABN when ordering.
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection is not available in your area through Quest Mobile.

Clinical Significance

RET/PTC Rearrangement, Thyroid Cancer - RET/PTC gene fusion is detected in 5-40% of papillary thyroid carcinomas, but has been reported at low frequency in other types of thyroid lesions. Correlation with morphologic and clinical findings is thus required.
The assay tests for both RET/PTC1 and RET/PTC3 rearrangements using a reverse transcription PCR assay. The lower limit of sensitivity is approximately 2.5% mutation-bearing cells in a mixed sample, but can vary due to RNA preservation.

Test Resources

None found for this test
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Test Details

Includes

  • RET/PTC1, RET/PTC3

Methodology

Real-Time Polymerase Chain Reaction (PCR)

Assay Category

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

RET/PTC1Not detected
RET/PTC3Not detected

Alternative Name(s)

Papillary Thyroid Cancer

LOINC® Codes, Performing Laboratory

Service Area must be determined
RET/PTC1, RET/PTC3

Methodology

Real-Time Polymerase Chain Reaction (PCR)
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

RET/PTC1Not detected
RET/PTC3Not detected

Alternative Name(s)

Papillary Thyroid Cancer
Service Area must be determined

Preferred Specimen(s)

1 formalin-fixed, paraffin-embedded tissue block or needle washing

Minimum Volume

1 tissue block or needle washing

Collection Instructions

⁠⁠⁠⁠⁠⁠⁠Do not reject. Needle washings in alcohol-based fixative (e.g. CytoLyt®) or formalin-fixed, paraffin-embedded tissue block FNA or FFPE specimens are acceptable for the assay.
All specimens must be accompanied with Pathology report. All FFPE specimens will be examined by a pathologist for confirmation and adequacy. Macrodissection if warranted is performed in the lab.

Transport Container

Paraffin-embedded tissue block

Transport Temperature

Room temperature

Specimen Stability

  • FNA or FFPE
  • Room temperature: 5 years
  • Refrigerated: 5 years
  • Frozen: Unacceptable
  •  
  • Needle washings
  • Room temperature: 30 days
  • Refrigerated: 30 days
  • Frozen: Unacceptable

Reject Criteria

Do not reject

Setup Schedule

Service Area must be determined
1 formalin-fixed, paraffin-embedded tissue block or needle washing
1 tissue block or needle washing
⁠⁠⁠⁠⁠⁠⁠Do not reject. Needle washings in alcohol-based fixative (e.g. CytoLyt®) or formalin-fixed, paraffin-embedded tissue block FNA or FFPE specimens are acceptable for the assay.
All specimens must be accompanied with Pathology report. All FFPE specimens will be examined by a pathologist for confirmation and adequacy. Macrodissection if warranted is performed in the lab.
Paraffin-embedded tissue block
Room temperature
FNA or FFPE
Room temperature: 5 years
Refrigerated: 5 years
Frozen: Unacceptable

Needle washings
Room temperature: 30 days
Refrigerated: 30 days
Frozen: Unacceptable
Do not reject
Service Area must be determined
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection is not available in your area through Quest Mobile.
Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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