von Willebrand Screen

von Willebrand Screen

Test Code

90271
85240, 85245, 85246, 85730
CPT Code is subject to a Medicare Limited Coverage Policy and may require a signed ABN when ordering.
90271
85240, 85245, 85246, 85730
CPT Code is subject to a Medicare Limited Coverage Policy and may require a signed ABN when ordering.
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano | Quest Nichols Institute -San Juan Capistrano, CA. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection is not available in your area through Quest Mobile.

Clinical Significance

von Willebrand Screen -

This test may be used for initial evaluation of individuals with clinical suspicion of von Willebrand disease (VWD).

von Willebrand factor (VWF) is a blood coagulation protein that has 2 functions: (1) mediating platelet adhesion to the injured endothelium and (2) acting as a protective carrier protein for coagulation factor VIII. Deficiency of VWF causes VWD, the most common inherited bleeding disorder that affects approximately 1 in 1,000 individuals at the primary care level [1]. VWD is classified into type 1 (quantitative deficiency of VWF), type 2 (qualitative deficiency of VWF), ...

Test Resources

None found for this test
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Test Details

Includes

  • Partial Thromboplastin Time, Activated
  • Factor VIII Activity, Clotting
  • von Willebrand Factor Antigen
  • Ristocetin Cofactor

Methodology

See individual tests

Reference Range(s)

See individual tests

Alternative Name(s)

Factor VIII Functional,Procoagulant Factor 8,Antihemophilic Factor,RcoF,von Willebrand Factor Activity,Hemophilia A,Hemophiliac Factor

LOINC® Codes, Performing Laboratory

Service Area must be determined
Partial Thromboplastin Time, Activated
Factor VIII Activity, Clotting
von Willebrand Factor Antigen
Ristocetin Cofactor

Methodology

See individual tests

Reference Range(s)

See individual tests

Alternative Name(s)

Factor VIII Functional,Procoagulant Factor 8,Antihemophilic Factor,RcoF,von Willebrand Factor Activity,Hemophilia A,Hemophiliac Factor
Service Area must be determined

Preferred Specimen(s)

3 mL frozen platelet-poor plasma collected in 3.2% sodium citrate (light blue-top) tubes

Collection Instructions

Platelet-poor plasma: Centrifuge light blue-top tube for 15 minutes at approximately 1500 g within 60 minutes of collection. Using a plastic pipette, remove plasma, taking care to avoid the WBC/platelet buffy layer and place into a plastic vial. Centrifuge a second time and transfer platelet-poor plasma into a new plastic vial. Plasma must be free of platelets (<10,000/mcl). Freeze immediately and ship on dry ice.

Note: Storage of whole blood at refrigerated temperatures prior to processing may lead to cryoprecipitate formation and falsely low Factor VIII and von Willebrand Factor studies.

Transport Container

Transport tube

Transport Temperature

Frozen

Specimen Stability

  • Room temperature: Unacceptable
  • Refrigerated: Unacceptable
  • Frozen: 14 days

Reject Criteria

Hemolysis • Lipemia • Thawed plasma received room temperature or refrigerated • Received room temperature • Received refrigerated • Received thawed

Setup Schedule

Service Area must be determined
3 mL frozen platelet-poor plasma collected in 3.2% sodium citrate (light blue-top) tubes
Platelet-poor plasma: Centrifuge light blue-top tube for 15 minutes at approximately 1500 g within 60 minutes of collection. Using a plastic pipette, remove plasma, taking care to avoid the WBC/platelet buffy layer and place into a plastic vial. Centrifuge a second time and transfer platelet-poor plasma into a new plastic vial. Plasma must be free of platelets (<10,000/mcl). Freeze immediately and ship on dry ice.

Note: Storage of whole blood at refrigerated temperatures prior to processing may lead to cryoprecipitate formation and falsely low Factor VIII and von Willebrand Factor studies.
Transport tube
Frozen
Room temperature: Unacceptable
Refrigerated: Unacceptable
Frozen: 14 days
Hemolysis • Lipemia • Thawed plasma received room temperature or refrigerated • Received room temperature • Received refrigerated • Received thawed
Service Area must be determined
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano | Quest Nichols Institute -San Juan Capistrano, CA. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection is not available in your area through Quest Mobile.
Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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