Sjogren's Panel with Rheumatoid Factor and ANA, IFA with Reflex
Test Code
Clinical Significance
Sjogren's Panel with Rheumatoid Factor and ANA, IFA with Reflex -
This panel can be helpful in the diagnosis of Sjogren syndrome by simultaneously testing for antinuclear antibodies (ANAs) with an immunofluorescence assay (IFA), performed on human epithelial type 2 (HEp-2) cells, as well as SSA antibodies, SSB antibodies, and rheumatoid factor (RF). For specimens with positive ANA IFA results, reflex testing for ANA titer and pattern is performed.
The laboratory evaluation for individuals with clinical suspicion of autoimmune diseases often begins with an ANA screen. The classic ANA IFA on HEp-2 cells is considered by the American College of Rheumatology ...
Test Resources
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Test Details
Sjogren's Antibodies (SS-A, SS-B)
Rheumatoid Factor
If ANA Screen, IFA is positive, then ANA Titer and Pattern will be performed at an additional charge (CPT code(s): 86039).
Methodology
Reference Range(s)
| ANA Screen, IFA | Negative |
| ANA Titer | |
| <1:80 | Negative |
| 1:80 | Low antibody level |
| >1:80 | Elevated antibody level |
| Sjögren's Antibody (SS-A) | <1.0 Negative AI |
| Sjögren's Antibody (SS-B) | <1.0 Negative AI |
| Rheumatoid Factor | <14 IU/mL |
Alternative Name(s)
Preferred Specimen(s)
2 mL serum
Minimum Volume
1.5 mL
Transport Container
Transport tube
Transport Temperature
Room temperature
Specimen Stability
- Room temperature: 4 days
- Refrigerated: 7 days
- Frozen: 30 days
Reject Criteria
Gross hemolysis • Grossly lipemic • Grossly icteric • Microbial contamination may interfere
Setup Schedule
Refrigerated: 7 days
Frozen: 30 days