Protein C Activity and Antigen

Test Code

8757

CPT Code(s)

85302, 85303

Test Code

8757

CPT Code(s)

85302, 85303

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.

In-home collection is not available in your area through Quest Mobile.

Clinical Significance

Protein C Activity and Antigen - Aids in characterization of protein C deficiency. Type I deficiency is characterized by reduction in activity (functional) and antigen levels. With type II deficiency (dysfunctional protein), antigen levels may be normal and activity levels are decreased. Acquired deficiencies may occur with vitamin K antagonists/deficiency, liver disease, malignancy, consumptive DIC, surgery, trauma, and hepatic immaturity of the newborn. Drug therapy with L-asparaginase or fluorouracil can also reduce Protein C antigen levels.

Anticoagulant interference: Expected impact by therapeutic levels (potential ...

Test Resources

None found for this test
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Test Details

Methodology

Clotting Assay • Immunoassay (IA)

Reference Range(s)

Protein C Activity
0-15 years	No reference range available
≥16 years	70-180 % normal
Protein C Antigen
0-15 years	No reference range available
≥16 years	70-140 % normal

Alternative Name(s)

PC Activity,PC Antigen,Protein C

LOINC® Codes, Performing Laboratory

Service Area must be determined

Methodology

Clotting Assay • Immunoassay (IA)

Reference Range(s)

Protein C Activity
0-15 years	No reference range available
≥16 years	70-180 % normal
Protein C Antigen
0-15 years	No reference range available
≥16 years	70-140 % normal

Alternative Name(s)

PC Activity,PC Antigen,Protein C

LOINC® Codes, Performing Laboratory

Service Area must be determined

Preferred Specimen(s)

2 mL frozen plasma (1 mL in two separate tubes) collected in a 3.2% sodium citrate (light blue-top) tube

Minimum Volume

0.5 mL (x2)

Collection Instructions

Please submit a separate, frozen vial for each special coagulation assay ordered. Draw blood in a light blue-top tube containing 3.2% sodium citrate, mix gently by inverting 3-4 times. Centrifuge 15 minutes at 1500 g within one hour of collection. Using a plastic pipette, remove plasma, taking care to avoid the WBC/platelet buffy layer and place into a plastic vial. Centrifuge a second time and transfer platelet-poor plasma into a new plastic vial(s). Freeze immediately and transport on dry ice.

Transport Container

Transport tubes (x2)

Transport Temperature

Frozen

Specimen Stability

Room temperature: Unacceptable
Refrigerated: Unacceptable
Frozen: 14 days

Reject Criteria

Gross hemolysis

Setup Schedule

Service Area must be determined

Preferred Specimen(s)

2 mL frozen plasma (1 mL in two separate tubes) collected in a 3.2% sodium citrate (light blue-top) tube

Minimum Volume

0.5 mL (x2)

Collection Instructions

Transport Container

Transport tubes (x2)

Transport Temperature

Frozen

Specimen Stability

Room temperature: Unacceptable
Refrigerated: Unacceptable
Frozen: 14 days

Reject Criteria

Gross hemolysis

Setup Schedule

Service Area must be determined

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.

In-home collection is not available in your area through Quest Mobile.

Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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