Bupropion and Metabolite, Serum/Plasma

Bupropion and Metabolite, Serum/Plasma

Test Code

8592
80299
CPT Code is subject to a Medicare Limited Coverage Policy and may require a signed ABN when ordering.
8592
80299
CPT Code is subject to a Medicare Limited Coverage Policy and may require a signed ABN when ordering.
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection is not available in your area through Quest Mobile.

Clinical Significance

Bupropion and Metabolite, Serum/Plasma - Bupropion is an antidepressant for treating mental depression. Monitoring its level is important to optimize therapy, to avoid toxicity and to assure compliance.

Test Resources

Topic Brief

Drug Half-Life, Steady State, and Recommended Sample Collection Time

Test Details

Includes

  • Bupropion and Hydroxybupropion

Patient Preparation

Collect as a trough prior to next dose

Methodology

Chromatography/Mass Spectrometry

Assay Category

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

Bupropion 50-100 ng/mL
Hydroxybupropion 600-2000 ng/mL

LOINC® Codes, Performing Laboratory

Service Area must be determined
Bupropion and Hydroxybupropion
Collect as a trough prior to next dose

Methodology

Chromatography/Mass Spectrometry
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

Bupropion 50-100 ng/mL
Hydroxybupropion 600-2000 ng/mL
Service Area must be determined

Preferred Specimen(s)

1 mL frozen serum collected in a red-top tube (no gel)

Alternative Specimen(s)

Plasma collected in: EDTA (lavender-top) tube

Minimum Volume

0.4 mL

Collection Instructions

Collect serum and remove from cells

Transport Container

Transport tube

Transport Temperature

Frozen

Specimen Stability

  • Room temperature: Unacceptable
  • Refrigerated: Unacceptable
  • Frozen: 30 days

Reject Criteria

Received room temperature • Received refrigerated • Gel barrier/serum separator tube (SST)

Setup Schedule

Service Area must be determined
1 mL frozen serum collected in a red-top tube (no gel)
Plasma collected in: EDTA (lavender-top) tube
0.4 mL
Collect serum and remove from cells
Transport tube
Frozen
Room temperature: Unacceptable
Refrigerated: Unacceptable
Frozen: 30 days
Received room temperature • Received refrigerated • Gel barrier/serum separator tube (SST)
Service Area must be determined
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection is not available in your area through Quest Mobile.
Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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