Aspartate Aminotransferase (AST)
Test Code
Clinical Significance
Aspartate Aminotransferase (AST) - AST is widely distributed throughout the tissues with significant amounts being in the heart and liver. Lesser amounts are found in skeletal muscles, kidneys, pancreas, spleen, lungs, and brain. Injury to these tissues results in the release of the AST enzyme to general circulation. In myocardial infarction, serum AST may begin to rise within 6-8 hours after onset, peak within two days and return to normal by the fourth or fifth day post infarction. An increase in serum AST is also found with hepatitis, liver necrosis, cirrhosis, and liver metastasis.
Test Resources
Clinical Focus
Autoimmune Rheumatic and Related DiseasesTest Details
Methodology
Reference Range(s)
| Male (U/L) | Female (U/L) | ||||
| <1 Month | 3-51 | 3-49 | |||
| 1-11 Months | 3-65 | 3-79 | |||
| 1-3 Years | 3-56 | 3-69 | |||
| 4-6 Years | 20-39 | 20-39 | |||
| 7-19 Years | 12-32 | 12-32 | |||
| 20-49 Years | 10-40 | ||||
| 20-44 Years | 10-30 | ||||
| ≥45 Years | 10-35 | ||||
| ≥50 Years | 10-35 |
Alternative Name(s)
Preferred Specimen(s)
1 mL serum
Alternative Specimen(s)
Sodium heparin (green-top) tube • Lithium heparin (green-top) tube
Minimum Volume
0.5 mL
Transport Container
Serum separator tube (SST)
Transport Temperature
Room temperature
Specimen Stability
- Serum and plasma
- Room temperature: 4 days
- Refrigerated: 7 days
- Frozen: 5 days
Reject Criteria
Hemolysis • Anticoagulants other than heparin
Setup Schedule
Room temperature: 4 days
Refrigerated: 7 days
Frozen: 5 days