Cholinesterase, Serum, with Dibucaine Inhibition

Test Code

7961

CPT Code(s)

82480, 82638

Test Code

7961

CPT Code(s)

82480, 82638

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.

In-home collection may be available in your area for purchase through Quest Mobile.

Clinical Significance

Cholinesterase, Serum, with Dibucaine Inhibition - The Pseudocholinesterase phenotype can be determined by analysis of Pseudocholinesterase and the percent inhibition by Dibucaine. Approximately 96% of the population has normal activity, approximately 4% will exhibit decreased activity that leads to prolonged paralysis following use of succinylcholine, and 1 in 3000 patients will exhibit severe, prolonged paralysis following anesthetic exposure.

Test Resources

None found for this test
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Test Details

Methodology

Kinetic Spectrophotometric (KS)

Assay Category

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

Cholinesterase, Serum
Male	3342-7586 IU/L
Female	2673-6592 IU/L
Dibucaine Number	81.6-88.3 % Inhibition

Cholinesterase with Dibucaine Inhibition

Phenotype	% Inhibition
U	83.6
A*	19.9
AS*	20.7
S1*	5.3
S2*	67.6
F*	71.8
AF*	60.2
FS*	76.7
UA	72.7
UF	79.8
US	84.4

* Phenotype reportedly associated with prolonged apnea.

Alternative Name(s)

Pseudocholinesterase

LOINC® Codes, Performing Laboratory

Service Area must be determined

Methodology

Kinetic Spectrophotometric (KS)

Assay Category

Reference Range(s)

Cholinesterase, Serum
Male	3342-7586 IU/L
Female	2673-6592 IU/L
Dibucaine Number	81.6-88.3 % Inhibition

Cholinesterase with Dibucaine Inhibition

Phenotype	% Inhibition
U	83.6
A*	19.9
AS*	20.7
S1*	5.3
S2*	67.6
F*	71.8
AF*	60.2
FS*	76.7
UA	72.7
UF	79.8
US	84.4

* Phenotype reportedly associated with prolonged apnea.

Alternative Name(s)

Pseudocholinesterase

LOINC® Codes, Performing Laboratory

Service Area must be determined

Preferred Specimen(s)

1 mL serum

Minimum Volume

0.5 mL

Transport Container

Transport tube

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 21 days
Refrigerated: 21 days
Frozen: 30 days

Reject Criteria

Hemolysis

Setup Schedule

Service Area must be determined

Preferred Specimen(s)

1 mL serum

Minimum Volume

0.5 mL

Transport Container

Transport tube

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 21 days
Refrigerated: 21 days
Frozen: 30 days

Reject Criteria

Hemolysis

Setup Schedule

Service Area must be determined

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.

In-home collection may be available in your area for purchase through Quest Mobile.

Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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