Creatinine Clearance
Test Code
Clinical Significance
Creatinine Clearance - Creatinine Clearance is used to evaluate the glomerular filtration rate (GFR). Clearance is defined as that volume of plasma from which a measured amount of substance could be completely eliminated into the urine per unit of time. Daily creatinine production is fairly constant except when there is massive injury to muscle.
Test Resources
Test Details
eGFR
Creatinine Clearance (calculation)
CPT code 81050 may be added at an additional charge for volume measurement
Methodology
Reference Range(s)
| Creatinine | ||
| Age | Male (mg/dL) | Female (mg/dL) |
| ≤2 days | 0.79-1.58 | 0.79-1.58 |
| 3-27 days | 0.35-1.23 | 0.35-1.23 |
| 1 month-9 years | 0.20-0.73 | 0.20-0.73 |
| 10-12 years | 0.30-0.78 | 0.30-0.78 |
| 13-15 years | 0.40-1.05 | 0.40-1.00 |
| 16-17 years | 0.60-1.20 | 0.50-1.00 |
| 18-29 years | 0.60-1.24 | 0.50-0.96 |
| 30-39 years | 0.60-1.26 | 0.50-0.97 |
| 40-49 years | 0.60-1.29 | 0.50-0.99 |
| 50-59 years | 0.70-1.30 | 0.50-1.03 |
| 60-69 years | 0.70-1.35 | 0.50-1.05 |
| 70-79 years | 0.70-1.28 | 0.60-1.00 |
| ≥80 years | 0.70-1.22 | 0.60-0.95 |
| eGFR | ≥60 mL/min/1.73m2 |
| Creatinine, 24-Hour Urine | |
| <3 Years | Not established |
| 3-8 Years | 0.10-0.80 g/24 h |
| 9-12 Years | 0.20-1.40 g/24 h |
| 13-17 Years | 0.40-1.90 g/24 h |
| >17 Years | 0.50-2.15 g/24 h |
| Creatinine Clearance, Urine | |
| Male | 85-125 mL/min |
| Female | 75-115 mL/min |
Preferred Specimen(s)
10 mL aliquot from a well-mixed, 24-hour urine collection - no preservative
and 1 mL serum
Alternative Specimen(s)
Acidified urine • Urinalysis transport tube (yellow-top, blue fill line, preservative tube) • Serum collected in: Spun serum separator tube (SST) • Plasma collected in: Sodium heparin (green-top) tube or lithium heparin (green-top) tube
Minimum Volume
0.5 mL urine • 0.5 mL serum
Collection Instructions
Record total volume and collection duration on specimen container and test requisition. Indicate the patient's height (in feet and inches) and weight (in lbs.) on test requisition.
Note: A serum creatinine level must be collected within 24 hours of the beginning or ending of the urine collection.
Transport Container
Urine: Plastic screw-cap container
Serum: Transport tube
Transport Temperature
Room temperature
Specimen Stability
- Serum and urine
Room temperature: 7 days
Refrigerated: 7 days
Frozen: 28 days
Reject Criteria
Grossly icteric serum
Setup Schedule
and 1 mL serum
Note: A serum creatinine level must be collected within 24 hours of the beginning or ending of the urine collection.
Serum: Transport tube
Room temperature: 7 days
Refrigerated: 7 days
Frozen: 28 days