IgG Synthesis Rate/Index, CSF
Test Code
Clinical Significance
IgG Synthesis Rate/Index, CSF - The IgG Synthesis Rate/Index is useful in diagnosing and monitoring patients with multiple sclerosis and other inflammatory diseases involving the brain and meninges.
Test Resources
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Test Details
IgG (CSF and Serum)
IgG Index, CSF
Synthesis Rate IgG, CSF
Methodology
Reference Range(s)
Preferred Specimen(s)
2 mL CSF submitted in a sterile, plastic, leak-proof CSF container and 1 mL serum
Minimum Volume
1 mL CSF and 0.5 mL serum
Collection Instructions
Both CSF & serum are required specimens. It is preferred that the collection date and time be the same for both; however, it is acceptable for them to be drawn within 48 hours of each other. If no serum is supplied, the client will be contacted to confirm the order.
CSF collection tube #4 is preferred. Submitting 4th lumbar puncture collection tube minimizes blood contamination.
Transport Temperature: Refrigerate CSF specimens at 2-8° C in sterile, plastic CSF vial(s) and send refrigerated (cold packs) to the laboratory OR freeze CSF specimens at -20° C and send frozen samples to the laboratory on dry ice.
Transport Container
Plastic screw-cap vial
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
- Room temperature: 8 hours
- Refrigerated: 7 days
- Frozen: 90 days
Reject Criteria
Hemolysis • Received room temperature • Xanthochromia • RBCs • Hemolysis in CSF
Setup Schedule
CSF collection tube #4 is preferred. Submitting 4th lumbar puncture collection tube minimizes blood contamination.
Transport Temperature: Refrigerate CSF specimens at 2-8° C in sterile, plastic CSF vial(s) and send refrigerated (cold packs) to the laboratory OR freeze CSF specimens at -20° C and send frozen samples to the laboratory on dry ice.
Refrigerated: 7 days
Frozen: 90 days