Sm and Sm/RNP Antibodies

Test Code

7448

CPT Code(s)

86235 (x2)

Test Code

7448

CPT Code(s)

86235 (x2)

In-home collection may be available in your area for purchase through Quest Mobile.

Clinical Significance

Sm and Sm/RNP Antibodies - Antibodies to Sm are highly specific for systemic lupus erythematosus (SLE) and when present are considered a marker antibody. However, these antibodies are found in only 20% of patients with SLE.
RNP antibodies (also known as anti-u1 or ribonucleoprotein antibodies) are found in 45% of SLE patients but are also observed in numerous other disease states such as Sjögren's syndrome, scleroderma and polymyositis. Elevated levels of antibodies to RNP are seen in mixed connective tissue disease. In SLE, RNP antibodies have been associated with a relatively benign ...

Test Resources

None found for this test
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Test Details

Methodology

Immunoassay (IA)

Reference Range(s)

Sm Antibody	<1.0 AI	Negative
Sm/RNP Antibody	<1.0 AI	Negative

Alternative Name(s)

Anti-Ribonucleic Protein Antigen,Anti-ENA Antibody,ENA Antibodies,Ribonuclear Protein Antibody,Anti-Smith Antibody,RNP Antibody

LOINC® Codes, Performing Laboratory, Patient Preparation

Service Area must be determined

Methodology

Immunoassay (IA)

Reference Range(s)

Sm Antibody	<1.0 AI	Negative
Sm/RNP Antibody	<1.0 AI	Negative

Alternative Name(s)

Anti-Ribonucleic Protein Antigen,Anti-ENA Antibody,ENA Antibodies,Ribonuclear Protein Antibody,Anti-Smith Antibody,RNP Antibody

LOINC® Codes, Performing Laboratory, Patient Preparation

Service Area must be determined

Preferred Specimen(s)

1 mL serum

Minimum Volume

0.5 mL

Transport Container

Transport tube

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 4 days
Refrigerated: 7 days
Frozen: 30 days

Setup Schedule, Reject Criteria

Service Area must be determined

Preferred Specimen(s)

1 mL serum

Minimum Volume

0.5 mL

Transport Container

Transport tube

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 4 days
Refrigerated: 7 days
Frozen: 30 days

Setup Schedule, Reject Criteria

Service Area must be determined

In-home collection may be available in your area for purchase through Quest Mobile.

Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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