Lupus Anticoagulant Evaluation with Reflex

Lupus Anticoagulant Evaluation with Reflex

Test Code

7079
85613, 85730
CPT Code is subject to a Medicare Limited Coverage Policy and may require a signed ABN when ordering.
7079
85613, 85730
CPT Code is subject to a Medicare Limited Coverage Policy and may require a signed ABN when ordering.
In-home collection is not available in your area through Quest Mobile.

Clinical Significance

Lupus Anticoagulant Evaluation with Reflex - Lupus anticoagulants (LA) are members of a family of antibodies with phospholipid-protein specificity. LA may be defined as an immunoglobulin, IgG or IgM or a mixture of both, that interferes with one or more of the in-vitro phospholipid (PL) dependent tests of coagulation. These antibodies are not associated with a hemorrhagic diathesis, but rather have been linked to thrombotic events. In addition to thrombosis other clinical complications have been associated with the presence of LA. These include strokes, nonbacterial thrombotic endocarditis, livedo reticularis and a variety of obstetrical ...

Test Resources

Test FAQ

Lupus Anticoagulant (LA) Evaluation with Reflex

Specimen Handling - Specimen Collection Video

Preparing Platelet-Poor Plasma for Coagulation Testing Video

Test Details

Includes

  • PTT-LA and dRVVT with Reflex Confirmations

    If PTT-LA Screen is prolonged (>40 seconds), then Hexagonal Phase Confirmation will be performed at an additional charge (CPT code(s): 85598).
    ⁠⁠⁠⁠⁠⁠⁠If Hexagonal Phase Confirmation is positive or weakly positive, then Thrombin Clotting Time will be performed at an additional charge (CPT code(s): 85670).

    If dRVVT Screen is prolonged (>45 seconds), then dRVVT Confirm will be performed at an additional charge (CPT code(s): 85597).
    If dRVVT Confirm is positive, then dRVVT 1:1 Mixing Study will be performed at an additional charge (CPT code(s): 85613).

Methodology

Clot detection

Reference Range(s)

Lupus Anticoagulant Not detected
PTT-LA Screen ≤40 sec
dRVVT Screen ≤45 sec

LOINC® Codes, Performing Laboratory

Service Area must be determined
PTT-LA and dRVVT with Reflex Confirmations

If PTT-LA Screen is prolonged (>40 seconds), then Hexagonal Phase Confirmation will be performed at an additional charge (CPT code(s): 85598).
⁠⁠⁠⁠⁠⁠⁠If Hexagonal Phase Confirmation is positive or weakly positive, then Thrombin Clotting Time will be performed at an additional charge (CPT code(s): 85670).

If dRVVT Screen is prolonged (>45 seconds), then dRVVT Confirm will be performed at an additional charge (CPT code(s): 85597).
If dRVVT Confirm is positive, then dRVVT 1:1 Mixing Study will be performed at an additional charge (CPT code(s): 85613).

Methodology

Clot detection

Reference Range(s)

Lupus Anticoagulant Not detected
PTT-LA Screen ≤40 sec
dRVVT Screen ≤45 sec
Service Area must be determined

Preferred Specimen(s)

3 mL frozen, platelet-poor plasma collected in a 3.2% sodium citrate (light blue-top) tube

Minimum Volume

2 mL

Collection Instructions

Platelet-poor plasma: Centrifuge light blue-top tube for 15 minutes at approximately 1500 g within 60 minutes of collection. Using a plastic pipette, remove plasma, taking care to avoid the WBC/platelet buffy layer and place into a plastic vial. Centrifuge a second time and transfer platelet-poor plasma into a new plastic vial. Plasma must be free of platelets (<10,000/mcL). Freeze immediately and ship on dry ice.

Transport Container

Transport tube

Transport Temperature

Frozen

Specimen Stability

  • Room temperature: Unacceptable
    Refrigerated: Unacceptable
    Frozen: 30 days

Reject Criteria

Hemolysis • Received thawed

Setup Schedule

Service Area must be determined
3 mL frozen, platelet-poor plasma collected in a 3.2% sodium citrate (light blue-top) tube
2 mL
Platelet-poor plasma: Centrifuge light blue-top tube for 15 minutes at approximately 1500 g within 60 minutes of collection. Using a plastic pipette, remove plasma, taking care to avoid the WBC/platelet buffy layer and place into a plastic vial. Centrifuge a second time and transfer platelet-poor plasma into a new plastic vial. Plasma must be free of platelets (<10,000/mcL). Freeze immediately and ship on dry ice.
Transport tube
Frozen
Room temperature: Unacceptable
Refrigerated: Unacceptable
Frozen: 30 days
Hemolysis • Received thawed
Service Area must be determined
In-home collection is not available in your area through Quest Mobile.
Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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