Catecholamines, Fractionated, Random Urine

Test code

5244

CPT code(s)*

82384, 82570

In-home collection is not available in your area through Quest Mobile.

Clinical significance

Catecholamines, Fractionated, Random Urine - This panel may aid in evaluating catecholamine-producing pheochromocytomas and paragangliomas (PPGLs). However, measurements of plasma free or urinary fractionated metanephrines (ie, the O-methylated catecholamine metabolites) are preferred for the initial biochemical evaluation of PPGLs because of their overall high diagnostic sensitivity [1]. To adjust for the concentration differences in random urine specimens, results are expressed as catecholamine to creatinine ratios.Most PPGLs secrete catecholamines and can cause catecholamine excess, resulting in hypertension, arrhythmia, and hyperglycemia. Left untreated,…

Test resources

None found for this test
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Details

Test details

Includes

Epinephrine, Norepinephrine, Calculated Total (E+NE), and Creatinine

Methodology

Liquid Chromatography/Mass Spectrometry (LC/MS)

Assay category

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Specimen requirements
Patient preparation	It is preferable for the patient to be off medications for a minimum of 18-24 hours prior to collection. However, common antihypertensives (diuretics, ACE inhibitors, calcium channel blockers, alpha and beta blockers) cause minimal or no interference. Patient should avoid alcohol, coffee, tea, tobacco and strenuous exercise for 8-12 hours prior to collection.
Preferred specimen(s)	1 mL urine with 6N HCl collected in a plastic urine container
Alternative specimen(s)	Unpreserved urine with pH ≤6
Minimum volume	0.7 mL
Transport container	Plastic urine container
Transport temperature	Frozen
Specimen stability	Preserved urine Room temperature: Unacceptable Refrigerated: 30 days Frozen: 60 days Unpreserved urine Room temperature: Unacceptable Refrigerated: 7 days Frozen: 60 days

Reference range(s)

Reference Range(s)

See Laboratory Report

LOINC® codes

The Result and LOINC® information listed below should not be used for electronic interface maintenance with Quest Diagnostics. Please contact the Quest Diagnostics Connectivity Help Desk for more information at 800-697-9302.

NOTE: The codes listed in the table are not orderable Test Codes

Result code	Result name	LOINC code	Component name
85993486	EPINEPHRINE	13734-9	EPINEPHrine/Creatinine
85993487	NOREPINEPHRINE	13782-8	Norepinephrine/Creatinine
85993488	CALCULATED TOTAL (E+NE)	13735-6	Epinephrine+Norepinephrine/Creatinine
85993489	DOPAMINE	13733-1	DOPamine/Creatinine
85994878	CREATININE,RANDOM URINE	2161-8	Creatinine

Performing lab & setup schedule

Performing laboratory

Quest Diagnostics Nichols Institute-San Juan Capistrano, CA

33608 Ortega Highway

San Juan Capistrano, CA 92675-2042

Setup schedule

Set up: Mon-Sat; Report available: 3 days

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

*The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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