Catecholamines, Fractionated, Random Urine

Catecholamines, Fractionated, Random Urine

Test Code

5244
82384, 82570
5244
82384, 82570
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection is not available in your area through Quest Mobile.

Clinical Significance

Catecholamines, Fractionated, Random Urine - This panel may aid in evaluating catecholamine-producing pheochromocytomas and paragangliomas (PPGLs). However, measurements of plasma free or urinary fractionated metanephrines (ie, the O-methylated catecholamine metabolites) are preferred for the initial biochemical evaluation of PPGLs because of their overall high diagnostic sensitivity [1]. To adjust for the concentration differences in random urine specimens, results are expressed as catecholamine to creatinine ratios.

Most PPGLs secrete catecholamines and can cause catecholamine excess, resulting in hypertension, arrhythmia, and hyperglycemia. ...

Test Resources

None found for this test
Please visit our Clinical Education Center to stay informed on any future publications, webinars, or other education opportunities.

Test Details

Includes

  • Epinephrine, Norepinephrine, Calculated Total (E+NE), and Creatinine

Patient Preparation

It is preferable for the patient to be off medications for a minimum of 18-24 hours prior to collection. However, common antihypertensives (diuretics, ACE inhibitors, calcium channel blockers, alpha and beta blockers) cause minimal or no interference.
Patient should avoid alcohol, coffee, tea, tobacco and strenuous exercise for 8-12 hours prior to collection.

Methodology

Liquid Chromatography/Mass Spectrometry (LC/MS)

Assay Category

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

See Laboratory Report

LOINC® Codes, Performing Laboratory

Service Area must be determined
Epinephrine, Norepinephrine, Calculated Total (E+NE), and Creatinine
It is preferable for the patient to be off medications for a minimum of 18-24 hours prior to collection. However, common antihypertensives (diuretics, ACE inhibitors, calcium channel blockers, alpha and beta blockers) cause minimal or no interference.
Patient should avoid alcohol, coffee, tea, tobacco and strenuous exercise for 8-12 hours prior to collection.

Methodology

Liquid Chromatography/Mass Spectrometry (LC/MS)
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

See Laboratory Report

Service Area must be determined

Preferred Specimen(s)

1 mL urine with 6N HCl collected in a plastic urine container

Alternative Specimen(s)

Unpreserved urine with pH ≤6

Minimum Volume

0.7 mL

Transport Container

Plastic urine container

Transport Temperature

Frozen

Specimen Stability

  • Preserved urine
    Room temperature: Unacceptable
    Refrigerated: 30 days
    Frozen: 60 days

    Unpreserved urine
    Room temperature: Unacceptable
    Refrigerated: 7 days
    Frozen: 60 days

Setup Schedule

Service Area must be determined
1 mL urine with 6N HCl collected in a plastic urine container
Unpreserved urine with pH ≤6
0.7 mL
Plastic urine container
Frozen
Preserved urine
Room temperature: Unacceptable
Refrigerated: 30 days
Frozen: 60 days

Unpreserved urine
Room temperature: Unacceptable
Refrigerated: 7 days
Frozen: 60 days
Service Area must be determined
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection is not available in your area through Quest Mobile.
Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

The tests listed by specialty and category are a select group of tests offered. For a complete list of Quest Diagnostics tests, please adjust the filter options chosen, or refer to our Directory of Services.

Customize the test information for your Service Area
We'd love your feedback! Take a brief survey.