Citric Acid, 24-Hour Urine with Creatinine
Test Code
Clinical Significance
Citric Acid, 24-Hour Urine with Creatinine - This quantitative citric acid test, performed with a 24-hour urine specimen, may help assess the risk of calcium stone formation in the kidneys and inform patient management [1]. In general, 24-hour urine specimens are preferred to random urine specimens when measuring citric acid for diagnostic evaluation and monitoring of calcium nephrolithiasis [2]. Because daily urine excretion of creatinine fluctuates little, creatinine excretion can help determine if 24-hour urine specimens for citric acid have been completely and accurately collected [1].
Citrate inhibits calcium stone formation by ...
Test Resources
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Test Details
Methodology
Reference Range(s)
Alternative Name(s)
Preferred Specimen(s)
10 mL aliquot of 24-hour urine collection
Minimum Volume
1.5 mL
Collection Instructions
Do not include first morning specimen; collect all subsequent voidings. The last sample collected should be the first morning specimen voided the following morning at the same time as the previous morning's first voiding. Specify 24-hour total volume on container and test requisition.
Transport Container
Plastic leak-proof urine container
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
- Room temperature: 8 hours
- Refrigerated: 30 days
- Frozen: 60 days
Reject Criteria
Received room temperature • Acidified urine
Setup Schedule
Refrigerated: 30 days
Frozen: 60 days