Creatine Kinase Isoenzymes (CK Isoenzymes) with Total CK

Test code

4451

CPT code(s)*

82550, 82552

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide Service Area Information to find available tests you can order.

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Clinical significance

Creatine Kinase Isoenzymes (CK Isoenzymes) with Total CK - This test measures creatine kinase (CK), an enzyme found primarily in striated muscle and heart tissue, and may be useful in assessing muscle damage. Total CK and fractions of CK isoenzymes are reported.CK is a dimeric enzyme composed of either 2 B subunits (CK-BB), 2 M subunits (CK-MM), or an M and a B subunit (CK-MB). CK-MM is the primary isoenzyme found in the skeletal muscle and heart tissue. CK-BB is mainly found in the brain and smooth muscle of gastrointestinal tract and urinary bladder. CK-MB is mainly found in the heart with a small amount in skeletal muscle [1].An increase in the CK level is often…

Test resources

None found for this test
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Details

Test details

Includes

CK-BB, CK-MB, CK-MM and Creatine Kinase (CK), Total

Methodology

Electrophoresis • Enzymatic

Alternative name(s)

CPK Isoenzymes

Specimen requirements
Patient preparation	None Specified
Preferred specimen(s)	2 mL frozen serum
Minimum volume	1 mL
Collection instructions	Allow blood to clot at room temperature for 30 minutes. Centrifuge immediately to separate the serum from cells and pour serum into a plastic transport tube. If CK and CK isoenzymes are ordered together, specimen must be submitted frozen.
Transport container	Transport tube
Transport temperature	Frozen
Specimen stability	Room temperature: Unacceptable Refrigerated: 48 hours Frozen: 14 days
Reject criteria	Hemolysis • Received thawed

Reference range(s)

See Laboratory Report

LOINC® codes

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Service Area Information

Performing lab & setup schedule

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Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

*The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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