Amitriptyline

Amitriptyline

Test Code

423
80299
423
80299
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection may be available in your area for purchase through Quest Mobile.

Clinical Significance

Amitriptyline - The tricyclics are used to treat depression. Nortriptyline is an active metabolite of Amitriptyline. Therapeutic drug levels are monitored to assist the physician assessing therapeutic response and to avoid toxicity.

Test Resources

Topic Brief

Drug Half-Life, Steady State, and Recommended Sample Collection Time

Test Details

Includes

  • Amitriptyline, Nortriptyline and Total

Patient Preparation

Collect at steady-state trough concentration. Specimen should be collected >12 hours after dose.

Methodology

Chromatography/Mass Spectrometry

Assay Category

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

Total 100-250 mcg/L

Alternative Name(s)

Triavil,Amitriptyline & Metabolite,Elavil®,Limbitrol®,Amitril,Endep,Etrafon

LOINC® Codes, Performing Laboratory

Service Area must be determined
Amitriptyline, Nortriptyline and Total
Collect at steady-state trough concentration. Specimen should be collected >12 hours after dose.

Methodology

Chromatography/Mass Spectrometry
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

Total 100-250 mcg/L

Alternative Name(s)

Triavil,Amitriptyline & Metabolite,Elavil®,Limbitrol®,Amitril,Endep,Etrafon
Service Area must be determined

Preferred Specimen(s)

3 mL serum collected in a red-top tube (no gel)

Alternative Specimen(s)

Plasma collected in: EDTA (lavender-top) tube, sodium heparin (green-top) tube or lithium heparin (green-top) tube

Minimum Volume

1.5 mL

Transport Container

Transport tube

Transport Temperature

Room temperature

Specimen Stability

  • Room temperature: 5 days
  • Refrigerated: 7 days
  • Frozen: 30 days

Reject Criteria

Gross hemolysis • Gel barrier/Serum separator tube (SST)

Setup Schedule

Service Area must be determined
3 mL serum collected in a red-top tube (no gel)
Plasma collected in: EDTA (lavender-top) tube, sodium heparin (green-top) tube or lithium heparin (green-top) tube
1.5 mL
Transport tube
Room temperature
Room temperature: 5 days
Refrigerated: 7 days
Frozen: 30 days
Gross hemolysis • Gel barrier/Serum separator tube (SST)
Service Area must be determined
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection may be available in your area for purchase through Quest Mobile.
Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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