Erythropoietin with Anemia Table

Test Code

40061

CPT Code(s)

82668

Test Code

40061

CPT Code(s)

82668

This test is not available in all locations. Please provide SERVICE AREA INFORMATION to confirm Test Code for the lab that services your account or to find available tests you can order.

In-home collection may be available in your area for purchase through Quest Mobile.

Clinical Significance

Erythropoietin with Anemia Table - Elevated levels of serum erythropoietin (epo) occur in patients with anemias due to increased red cell destruction in hemolytic anemia and also in secondary polycythemias associated with impaired oxygen delivery to the tissues, impaired pulmonary oxygen exchange, abnormal hemoglobins with increased oxygen affinity, construction of the renal vasculature, and inappropriate epo secretion caused by certain renal and extrarenal tumors. Normal or depressed levels may occur in anemias due to increased oxygen delivery to tissues, in hypophosphatemia, and in polycythemia vera.

Test Resources

None found for this test
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Test Details

Patient Preparation

Due to diurnal variation, it is recommended that specimens be collected between 7:30 a.m. and noon

Methodology

Immunoassay (IA)

Reference Range(s)

	Male (mIU/mL)	Female (mIU/mL)
<1 year	Not established	Not established
1-3 years	1.7-17.9	2.1-15.9
4-6 years	3.5-21.9	2.9-8.5
7-9 years	1.0-13.5	2.1-8.2
10-12 years	1.0-14.0	1.1-9.1
13-15 years	2.2-14.4	3.8-20.5
16-18 years	1.5-15.2	2.0-14.2
>18 years	2.6-18.5	2.6-18.5

The erythropoietin reference range is based on individuals with normal hemoglobin and hematocrit values. Intervals provided below for general guidance are the 10-90 percentile ranges for anemic adults, obtained using a different but similarly-performing EPO immunoassay (Siemens Immulite 2000).

Anemic adults

Hgb (g/dL)	Erythropoietin (mIU/mL)
≤8.0	42.3-582.0
8.1-9.0	29.7-450.0
9.1-10.0	24.3-178.0
10.1-11.0	13.5-93.8

Adapted from Clin Lab (2002) 48:595-598

LOINC® Codes, Performing Laboratory

Service Area must be determined

Patient Preparation

Due to diurnal variation, it is recommended that specimens be collected between 7:30 a.m. and noon

Methodology

Immunoassay (IA)

Reference Range(s)

	Male (mIU/mL)	Female (mIU/mL)
<1 year	Not established	Not established
1-3 years	1.7-17.9	2.1-15.9
4-6 years	3.5-21.9	2.9-8.5
7-9 years	1.0-13.5	2.1-8.2
10-12 years	1.0-14.0	1.1-9.1
13-15 years	2.2-14.4	3.8-20.5
16-18 years	1.5-15.2	2.0-14.2
>18 years	2.6-18.5	2.6-18.5

Hgb (g/dL)	Erythropoietin (mIU/mL)
≤8.0	42.3-582.0
8.1-9.0	29.7-450.0
9.1-10.0	24.3-178.0
10.1-11.0	13.5-93.8

Adapted from Clin Lab (2002) 48:595-598

LOINC® Codes, Performing Laboratory

Service Area must be determined

Preferred Specimen(s)

1 mL serum

Minimum Volume

0.5 mL

Transport Container

Serum separator tube (SST)

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 10 days
Refrigerated: 18 days
Frozen: 28 days

Setup Schedule

Service Area must be determined

Preferred Specimen(s)

1 mL serum

Minimum Volume

0.5 mL

Transport Container

Serum separator tube (SST)

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 10 days
Refrigerated: 18 days
Frozen: 28 days

Setup Schedule

Service Area must be determined

This test is not available in all locations. Please provide ACCOUNT INFORMATION NEEDED to confirm Test Code for the lab that services your account or to find available tests you can order.

In-home collection may be available in your area for purchase through Quest Mobile.

Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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