FISH, MALT Lymphoma, API2/MALT1, t(11;18)

Test Code

40056

CPT Code(s)

88271 (x2), 88275

CPT Code is subject to a Medicare Limited Coverage Policy and may require a signed ABN when ordering.

Test Code

40056

CPT Code(s)

88271 (x2), 88275

CPT Code is subject to a Medicare Limited Coverage Policy and may require a signed ABN when ordering.

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.

In-home collection is not available in your area through Quest Mobile.

Clinical Significance

FISH, MALT Lymphoma, API2/MALT1, t(11;18) - This fluorescence in situ hybridization (FISH) assay detects the t(11;8) translocation that results in the BIRC3(API2)/MALT1fusion gene. The results of this test may aid in the diagnosis of extranodal marginal zone lymphoma of mucosa‐associated lymphoid tissue (MALT lymphoma).

MALT lymphomas-a subtype of marginal zone lymphomas-originate in marginal zone B cells and account for 5% to 8% of B-cell lymphomas [1]. The genetic abnormalities associated with MALT lymphoma include the following: t(11;18) that results in the BIRC3/MALT1fusion gene, t(14;18) ...

Test Resources

None found for this test
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Test Details

Methodology

Fluorescence in situ Hybridization (FISH)

Assay Category

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

See Laboratory Report

LOINC® Codes, Performing Laboratory

Service Area must be determined

Methodology

Fluorescence in situ Hybridization (FISH)

Assay Category

Reference Range(s)

See Laboratory Report

LOINC® Codes, Performing Laboratory

Service Area must be determined

Preferred Specimen(s)

3 mL bone marrow or 5 mL whole blood collected in a sodium heparin (green-top) tube

Alternative Specimen(s)

Formalin-fixed paraffin embedded tissue • 5x5 mm lymph node tissue or lymph node collected in a sterile container

Minimum Volume

1 mL

Transport Container

Sodium heparin (green-top) tube

Transport Temperature

Room temperature

Specimen Stability

Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.

Setup Schedule

Service Area must be determined

Preferred Specimen(s)

3 mL bone marrow or 5 mL whole blood collected in a sodium heparin (green-top) tube

Alternative Specimen(s)

Formalin-fixed paraffin embedded tissue • 5x5 mm lymph node tissue or lymph node collected in a sterile container

Minimum Volume

1 mL

Transport Container

Sodium heparin (green-top) tube

Transport Temperature

Room temperature

Specimen Stability

Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.

Setup Schedule

Service Area must be determined

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.

In-home collection is not available in your area through Quest Mobile.

Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

The tests listed by specialty and category are a select group of tests offered. For a complete list of Quest Diagnostics tests, please adjust the filter options chosen, or refer to our Directory of Services.