FISH, ALL, Extended Panel

Test Code

40050

CPT Code(s)

88271 (x16), 88275 (x8)

CPT Code is subject to a Medicare Limited Coverage Policy and may require a signed ABN when ordering.

Test Code

40050

CPT Code(s)

88271 (x16), 88275 (x8)

CPT Code is subject to a Medicare Limited Coverage Policy and may require a signed ABN when ordering.

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.

In-home collection is not available in your area through Quest Mobile.

Clinical Significance

FISH, ALL, Extended Panel - This panel uses fluorescence in situ hybridization (FISH) to detect an extended set of common genetic abnormalities associated with B-cell acute lymphoblastic leukemia (B-ALL) and may aid in risk stratification and treatment decisions. These genetic abnormalities include the following: MYC rearrangement, the CDKN2A deletion, IGH rearrangement, TCF3 (E2A) rearrangement resulting from the t(1;19)(q23;p13) translocation, the BCR/ABL1 fusion gene resulting from the t(9;22)(q34;q11.2) translocation, the ETV6/RUNX1 (TEL/AML1) fusion ...

Test Resources

None found for this test
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Test Details

Includes

11q (MLL), 4,10,17, 8q (MYC), 14q (IGH), t(9;22), t(12;21), 19p (E2A), 9p (CDKN2A)

Methodology

Fluorescence in situ Hybridization (FISH)

Assay Category

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

See Laboratory Report

LOINC® Codes, Performing Laboratory

Service Area must be determined

Includes

11q (MLL), 4,10,17, 8q (MYC), 14q (IGH), t(9;22), t(12;21), 19p (E2A), 9p (CDKN2A)

Methodology

Fluorescence in situ Hybridization (FISH)

Assay Category

Reference Range(s)

See Laboratory Report

LOINC® Codes, Performing Laboratory

Service Area must be determined

Preferred Specimen(s)

3 mL bone marrow or 5 mL whole blood collected in a sodium heparin (green-top) tube

Alternative Specimen(s)

Sodium heparin (royal blue-top) tube • Sodium heparin lead-free (tan-top) tube

Minimum Volume

1 mL

Transport Container

Sodium heparin (green-top) tube

Transport Temperature

Room temperature

Specimen Stability

Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not Reject.

Setup Schedule

Service Area must be determined

Preferred Specimen(s)

3 mL bone marrow or 5 mL whole blood collected in a sodium heparin (green-top) tube

Alternative Specimen(s)

Sodium heparin (royal blue-top) tube • Sodium heparin lead-free (tan-top) tube

Minimum Volume

1 mL

Transport Container

Sodium heparin (green-top) tube

Transport Temperature

Room temperature

Specimen Stability

Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not Reject.

Setup Schedule

Service Area must be determined

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.

In-home collection is not available in your area through Quest Mobile.

Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

The tests listed by specialty and category are a select group of tests offered. For a complete list of Quest Diagnostics tests, please adjust the filter options chosen, or refer to our Directory of Services.