Lyme Disease Antibody with Reflex to Immunoassay (IgG, IgM) (MTTT)

Lyme Disease Antibody with Reflex to Immunoassay (IgG, IgM) (MTTT)

Test Code

39733
86618
39733
86618
In-home collection may be available in your area for purchase through Quest Mobile.

Clinical Significance

Lyme Disease Antibody with Reflex to Immunoassay (IgG, IgM) (MTTT) - This test is for the qualitative detection of antibodies against Borrelia burgdorferi, the causative agent of Lyme disease, using the modified two-tier testing (MTTT) algorithm. Initial testing is performed using a Lyme total (IgG and IgM) antibody assay and if positive or equivocal, the sample is then tested using separate IgG and IgM immunoassays. This algorithm differs from the STTT algorithm in that the second-tier assays are chemiluminescent immunoassays, not immunoblots. MTTT may be able to assist in the identification of Lyme disease with improved sensitivity earlier in infection ...

Test Resources

Test FAQ

Lyme Disease Testing

Algorithm

An Approach to the Differential Diagnosis of Tick-borne Diseases

Algorithm

Serological Test Selection for the Differential Diagnosis of Tick-borne Diseases Based on Geographic Origin and Symptoms of Infection

Clinical Focus

Lyme Disease: Laboratory Support of Diagnosis and Management

Topic Brief

Tick-borne Disease: Laboratory Support of Diagnosis and Management

Test Details

Includes

  • If Lyme Disease Antibody is Positive or Equivocal (≥0.90), then Lyme Disease Supplemental Antibodies (IgG, IgM), Immunoassay will be performed at an additional charge (CPT code(s): 86617(x2)).

Methodology

Immunoassay (IA)

Reference Range(s)

Lyme Ab, Screen<0.90 index
  Lyme Ab (IgG)<0.90 index
  Lyme Ab (IgM)<0.90 index

Alternative Name(s)

Modified Two Tiered Test,Lyme Serology,Borrelia burgdorferi Antibodies,Lyme Disease,B burgdorferi,MTTT-2

LOINC® Codes, Performing Laboratory

Service Area must be determined
If Lyme Disease Antibody is Positive or Equivocal (≥0.90), then Lyme Disease Supplemental Antibodies (IgG, IgM), Immunoassay will be performed at an additional charge (CPT code(s): 86617(x2)).

Methodology

Immunoassay (IA)

Reference Range(s)

Lyme Ab, Screen<0.90 index
  Lyme Ab (IgG)<0.90 index
  Lyme Ab (IgM)<0.90 index

Alternative Name(s)

Modified Two Tiered Test,Lyme Serology,Borrelia burgdorferi Antibodies,Lyme Disease,B burgdorferi,MTTT-2
Service Area must be determined

Preferred Specimen(s)

1 mL serum

Minimum Volume

0.5 mL

Transport Container

Transport tube

Transport Temperature

Room temperature

Specimen Stability

  • Room temperature: 7 days
    Refrigerated: 14 days
    Frozen: 30 days

Reject Criteria

Gross hemolysis • Grossly lipemic • Grossly icteric

Setup Schedule

Service Area must be determined
1 mL serum
0.5 mL
Transport tube
Room temperature
Room temperature: 7 days
Refrigerated: 14 days
Frozen: 30 days
Gross hemolysis • Grossly lipemic • Grossly icteric
Service Area must be determined
In-home collection may be available in your area for purchase through Quest Mobile.
Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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