IgG/Albumin Ratio, CSF

IgG/Albumin Ratio, CSF

Test Code

39484
82042, 82784
39484
82042, 82784
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection is not available in your area through Quest Mobile.

Clinical Significance

IgG/Albumin Ratio, CSF -

This test may be helpful in the evaluation of intrathecal synthesis of IgG in individuals with clinical suspicion of inflammatory diseases of the central nervous system (CNS), especially multiple sclerosis [1]. Intrathecal synthesis of IgG can be more specifically demonstrated by paring IgG/albumin ratios in the cerebrospinal fluid (CSF) and serum to calculate IgG index [2].

Elevated IgG levels in the CSF may be caused by increased intrathecal synthesis of IgG, increased permeability of blood-brain barrier, or both. Because albumin is not synthesized or metabolized in the CSF, it can be ...

Test Resources

None found for this test
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Test Details

Includes

  • IgG, Albumin, and IgG/Albumin Ratio, CSF

Methodology

Nephelometry

Reference Range(s)

IgG, CSF 0.8-7.7 mg/dL
Albumin, CSF 8.0-42.0 mg/dL
IgG/Albumin Ratio <0.28

LOINC® Codes, Performing Laboratory

Service Area must be determined
IgG, Albumin, and IgG/Albumin Ratio, CSF

Methodology

Nephelometry

Reference Range(s)

IgG, CSF 0.8-7.7 mg/dL
Albumin, CSF 8.0-42.0 mg/dL
IgG/Albumin Ratio <0.28
Service Area must be determined

Preferred Specimen(s)

2 mL CSF collected in a sterile leak-proof container

Minimum Volume

1 mL

Collection Instructions

CSF must be clear

Transport Container

Sterile leak-proof container

Transport Temperature

Frozen

Specimen Stability

  • Room temperature: 72 hours
  • Refrigerated: 7 days
  • Frozen: 90 days

Reject Criteria

Hemolysis • Xanthochromia/RBCs in CSF

Setup Schedule

Service Area must be determined
2 mL CSF collected in a sterile leak-proof container
1 mL
CSF must be clear
Sterile leak-proof container
Frozen
Room temperature: 72 hours
Refrigerated: 7 days
Frozen: 90 days
Hemolysis • Xanthochromia/RBCs in CSF
Service Area must be determined
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection is not available in your area through Quest Mobile.
Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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