Borrelia Species DNA, Real-Time PCR, with Reflexes, Blood

Borrelia Species DNA, Real-Time PCR, with Reflexes, Blood

Test Code

39219
87801
CPT Code is subject to a Medicare Limited Coverage Policy and may require a signed ABN when ordering.
39219
87801
CPT Code is subject to a Medicare Limited Coverage Policy and may require a signed ABN when ordering.
In-home collection may be available in your area for purchase through Quest Mobile.

Clinical Significance

Borrelia Species DNA, Real-Time PCR, with Reflexes, Blood - The diagnosis of Borreliosis is most often made by clinical examination combined with exposure in endemic areas. Amplification of Borrelia genomic DNA from blood can support the diagnosis. This test detects Borrelia species which are associated with either Lyme disease (Borrelia burgdorferi), or relapsing fever (Borrelia miyamotoi). A positive result for Borrelia species but negative result for Borrelia burgdorferi and Borrelia miyamotoi, may indicate that infection is caused by other Borrelia species. A negative result for Borrelia species does not rule out Borrelia infection and appropriate serology testing may be clinically warranted.

Test Resources

Test FAQ

Lyme Disease Testing

Algorithm

Serological Test Selection for the Differential Diagnosis of Tick-borne Diseases Based on Geographic Origin and Symptoms of Infection

Clinical Focus

Lyme Disease: Laboratory Support of Diagnosis and Management

Topic Brief

Tick-borne Disease: Laboratory Support of Diagnosis and Management

Test Details

Includes

  • If Borrelia Species DNA, Real-Time PCR, Blood is Detected, then Borrelia burgdorferi DNA, Qualitative Real-Time PCR, Miscellaneous and Borrelia miyamotoi DNA, Real-Time PCR, Miscellaneous will be performed at an additional charge (CPT Code(s): 87476, 87478).

Methodology

Real-Time Polymerase Chain Reaction

Assay Category

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

Not detected

Alternative Name(s)

Lyme,Borreliosis,Tick borne

LOINC® Codes, Performing Laboratory

Service Area must be determined
If Borrelia Species DNA, Real-Time PCR, Blood is Detected, then Borrelia burgdorferi DNA, Qualitative Real-Time PCR, Miscellaneous and Borrelia miyamotoi DNA, Real-Time PCR, Miscellaneous will be performed at an additional charge (CPT Code(s): 87476, 87478).

Methodology

Real-Time Polymerase Chain Reaction
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

Not detected

Alternative Name(s)

Lyme,Borreliosis,Tick borne
Service Area must be determined

Preferred Specimen(s)

3 mL whole blood collected in an EDTA (lavender top) tube

Minimum Volume

0.5 mL

Transport Container

EDTA (lavender top) tube

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

  • Room temperature: 72 hours
    Refrigerated: 7 days
    Frozen: 30 days

Reject Criteria

Lithium heparin (green-top) tube • Sodium heparin (green-top) tube

Setup Schedule

Service Area must be determined
3 mL whole blood collected in an EDTA (lavender top) tube
0.5 mL
EDTA (lavender top) tube
Refrigerated (cold packs)
Room temperature: 72 hours
Refrigerated: 7 days
Frozen: 30 days
Lithium heparin (green-top) tube • Sodium heparin (green-top) tube
Service Area must be determined
In-home collection may be available in your area for purchase through Quest Mobile.
Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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