Beta-2-Microglobulin, Random Urine with Creatinine

Test code

38994

CPT code(s)*

82232, 82570

In-home collection is not available in your area through Quest Mobile.

Clinical significance

Beta-2-Microglobulin, Random Urine with Creatinine - Beta-2 Microglobulin (B2M) is a low molecular weight protein that forms the light chain component of the histocompatibility antigen. It is synthesized by all nucleated cell types. It is an integral part of the class I MHC antigens and is present in all body fluids. B2M is filtered through the glomeruli of the kidney and is then reabsorbed and catabolized by the proximal tubular cells. In normal patients only trace amounts of B2M appear in the urine. Elevated urine B2M is seen in tubulo-interstitial disorders. Increased urine B2M is seen in cadmium exposure, diatrizoate, exercise, fever, nephrectomy, semen. There is evidence that monitoring…

Test resources

Test guide

Solid Organ and Hematopoietic Stem Cell Transplantation Laboratory Testing for Donors and Recipients

Details

Test details

The information below details the components of this test. For overall setup schedule, see Performing lab & setup schedule.

Included components

Test code	Test name	Orderable separately	Setup schedule
%91205	BETA 2 MICROGLOBULIN WITHCREATININE, RANDOM UR	No	Not provided
%8459	CREATININE, RANDOM URINE	No	Not provided

Methodology

Immunoturbidimetric

Specimen requirements
Patient preparation	Patient should void bladder, then drink at least 500 mL of (approximately 17 oz) of water.
Preferred specimen(s)	10 mL urine collected in a Quest Diagnostics Beta-2 Microglobulin Transport Tube (available through Client Supply) and 10 mL urine collected in a plastic urine container for creatinine
Alternative specimen(s)	See Collection Instructions
Minimum volume	10 mL (Beta-2 Microglobulin Transport Tube) • 0.5 mL (Plastic urine container)
Collection instructions	⁠⁠⁠⁠⁠⁠⁠Beta-2 Microglobulin 1. Patient should void bladder, then drink at least 500 mL (approximately 17 oz) of water. 2. A urine sample should be collected within 1 hour. 3. Pour exactly 10 mL of random urine into a Quest Diagnostics Beta-2 Microglobulin Transport Tube (available through Client Supply). 4. Ship room temperature. 5. Alternatively, if the collection tubes are not available, pH of the specimen must be adjusted to between 6 and 8 using 1N NaOH prior to shipping. Beta-2 Microglobulin in urine is unstable in acidic urine (less than pH 6). Exactly 10 mL of urine in the Quest Diagnostics Beta-2 Microglobulin Transport Tube is required to achieve the required pH of between 6 and 8. Any volume of urine above or below 10 mL will result in a pH that is outside the acceptable range. Creatinine 1. Pour 10 mL of random unpreserved urine, collected in a plastic urine container into a plastic transport tube.
Transport container	See Collection Instructions
Transport temperature	Room temperature
Specimen stability	⁠⁠⁠⁠⁠⁠⁠Beta-2 urine Room temperature: 5 days Refrigerated: 15 days Frozen: 30 days Creatinine urine Room temperature: 7 days Refrigerated: 7 days Frozen: 28 days
Reject criteria	Specimens received in a non-Beta-2 Microglobulin transport tube with a pH <6 • Any volume other than 10 mL urine in the transport tube • Any specimen with pH <6

Reference range(s)

Reference Range(s)

B2 Microglobulin/Creatinine Ratio

≤132 mcg/g creat

Creatinine, Random Urine

≤6 Months	2-28 mg/dL
7-11 Months	2-31 mg/dL
1-2 Years	2-110 mg/dL
3-8 Years	2-130 mg/dL
9-12 Years	2-160 mg/dL
>12 Years Male	20-320 mg/dL
>12 Years Female	20-275 mg/dL

LOINC® codes

The Result and LOINC® information listed below should not be used for electronic interface maintenance with Quest Diagnostics. Please contact the Quest Diagnostics Connectivity Help Desk for more information at 800-697-9302.

NOTE: The codes listed in the table are not orderable Test Codes

Result code	Result name	LOINC code	Component name
25026500	CREATININE, RANDOM URINE	2161-8	Creatinine
45030600	BETA 2 MICROGLOBULIN/ CREATININE RATIO	13485-8	Beta-2-Microglobulin/Creatinine

Performing lab & setup schedule

Performing laboratory

Quest Diagnostics Nichols Institute-Chantilly VA

14225 Newbrook Drive

Chantilly, VA 20151-2228

Setup schedule

Information not provided in New England (MA, ME, RI, VT, Northern CT, NH) – Contact lab or Customer service to determine turnaround time

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

*The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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