Total Glutathione in Whole Blood
Test Code
Clinical Significance
Total Glutathione in Whole Blood - Glutathione is a tripeptide formed by a peptide linkage between the amine group of cysteine linked to glycine and the carboxyl group of the glutamate side-chain. It is an abundant cellular reducing agent, whose major biological function is mitigating oxidative damage to biological macromolecules. Glutathione is also important in the metabolism and excretion of xenobiotic compounds. Glutathione is consumed to maintain cells in a reduced condition. Consequently, glutathione levels in patient samples are expected to be diminished in disease states where oxygen reactive species are involved, such as ...
Test Resources
Please visit our Clinical Education Center to stay informed on any future publications, webinars, or other education opportunities.
Test Details
Methodology
Reference Range(s)
Preferred Specimen(s)
1 full tube of whole blood collected in an ACD solution B (yellow-top) tube
Minimum Volume
1 full tube
Collection Instructions
Do not centrifuge. Send whole tube. Solution B specimen volume is 6 mL. ACD collection tubes must be >50% filled in order to ensure proper mixture of ACD solution.
Transport Container
ACD solution B (yellow-top) tube
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
- Room temperature: Unacceptable
Refrigerated: 21 days
Frozen: Unacceptable
Reject Criteria
Hemolysis • Samples oversaturated with ACD solution
Setup Schedule
Refrigerated: 21 days
Frozen: Unacceptable