Orotic Acid, Urine with Creatinine

Test Code

38684

CPT Code(s)

83921, 82570

Test Code

38684

CPT Code(s)

83921, 82570

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.

In-home collection is not available in your area through Quest Mobile.

Clinical Significance

Orotic Acid, Urine with Creatinine - Orotic acid is an intermediate metabolite in the de novo pathway of pyrimidine nucleotide synthesis. When present at high levels in the blood, orotic acid accumulates in the liver, enters into the plasma, and is excreted by the kidney. There are several inherited metabolic disorders in which levels of orotic acid are increased. Certain medications can increase orotic acid levels as well.

Measurement of orotic acid levels in urine is useful in evaluating the causes of hyperammonemia. Urea cycle disorders are a common cause of inherited hyperammonemia; orotic acid is elevated in ornithine ...

Test Resources

None found for this test
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Test Details

Methodology

Chromatography/Mass Spectrometry

Assay Category

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

Orotic Acid

<2 weeks	0.7-4.5 mmol/mol crt
2 weeks-1 year	1.0-6.5 mmol/mol crt
2-10 years	0.2-3.4 mmol/mol crt
11-17 years	0.2-2.0 mmol/mol crt
≥18 years	0.2-2.8 mmol/mol crt

Creatinine, Random Urine

0-6 months	0.18-2.48 mmol/L
7-11 months	0.18-2.74 mmol/L
1-2 years	0.18-9.72 mmol/L
3-8 years	0.18-11.49 mmol/L
9-12 years	0.18-14.14 mmol/L
>12 years	1.77-23.31 mmol/L

LOINC® Codes, Performing Laboratory

Service Area must be determined

Methodology

Chromatography/Mass Spectrometry

Assay Category

Reference Range(s)

Orotic Acid

<2 weeks	0.7-4.5 mmol/mol crt
2 weeks-1 year	1.0-6.5 mmol/mol crt
2-10 years	0.2-3.4 mmol/mol crt
11-17 years	0.2-2.0 mmol/mol crt
≥18 years	0.2-2.8 mmol/mol crt

Creatinine, Random Urine

0-6 months	0.18-2.48 mmol/L
7-11 months	0.18-2.74 mmol/L
1-2 years	0.18-9.72 mmol/L
3-8 years	0.18-11.49 mmol/L
9-12 years	0.18-14.14 mmol/L
>12 years	1.77-23.31 mmol/L

LOINC® Codes, Performing Laboratory

Service Area must be determined

Preferred Specimen(s)

10 mL urine with no preservative collected in a sterile screw-cap container

Minimum Volume

0.6 mL

Collection Instructions

The following information should be provided with the specimen: Date of collection, age of the patient.
Urine samples should not have any preservatives added. Freeze as soon as possible after collection. Ship frozen. Do not thaw.

Transport Container

Sterile screw-cap container

Transport Temperature

Frozen

Specimen Stability

Room temperature: Unacceptable
Refrigerated: 7 days
Frozen: 28 days

Reject Criteria

Shipped refrigerated (2-8° C) • Samples with pH <2 • Fecal contamination

Setup Schedule

Service Area must be determined

Preferred Specimen(s)

10 mL urine with no preservative collected in a sterile screw-cap container

Minimum Volume

0.6 mL

Collection Instructions

Transport Container

Sterile screw-cap container

Transport Temperature

Frozen

Specimen Stability

Room temperature: Unacceptable
Refrigerated: 7 days
Frozen: 28 days

Reject Criteria

Shipped refrigerated (2-8° C) • Samples with pH <2 • Fecal contamination

Setup Schedule

Service Area must be determined

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.

In-home collection is not available in your area through Quest Mobile.

Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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