Aquaporin-4 (AQP4) (NMO-IgG) Antibody with Reflex to Titer, Serum

Test Code

38321

CPT Code(s)

86052

Test Code

38321

CPT Code(s)

86052

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.

In-home collection may be available in your area for purchase through Quest Mobile.

Clinical Significance

Aquaporin-4 (AQP4) (NMO-IgG) Antibody with Reflex to Titer, Serum - NMO (neuromyelitis optica, Devic disease) is an immune- mediated chronic inflammatory disease that predominantly affects the optic nerve and spinal cord and presents with optic neuritis (ON) and myelitis. Limited forms of this disease, such as isolated ON, brainstem encephalitis and longitudinal extensive transverses myelitis (LETM), have been referred to as NMO spectrum disorders (NMOSD). NMO was originally thought to be a variant of multiple sclerosis, but is now recognized as a distinct disease. The presence of serum antibodies against aquaporin-4 (AQP4) is associated with NMO and NMOSD.

Test Resources

Clinical Focus

NMOSD and MOGAD: Laboratory Support of Diagnosis and Management

Clinical Focus

Paraneoplastic Neurological Syndromes: Laboratory Support of Diagnosis

Test Details

Includes

If the Aquaporin 4 Antibody, Serum is positive, then Aquaporin 4 Antibody, Titer, Serum will be performed at an additional charge (CPT code: 86052).

Methodology

Cell-based Immunofluorescence Assay

Assay Category

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

Aquaporin 4 Ab, CBA, Serum	Negative
Aquaporin 4 Ab, Titer, Serum	<1:10 Titer

Alternative Name(s)

Transverse Myelitis Antibody,AQP4,NMO antibody,Aquaporin,LETM antibody,Optic Neuritis Antibody,Devic’s Antibody,NMO-IgG,Neuromyelitis Optica,NMOSD,AQP

LOINC® Codes, Performing Laboratory

Service Area must be determined

Includes

If the Aquaporin 4 Antibody, Serum is positive, then Aquaporin 4 Antibody, Titer, Serum will be performed at an additional charge (CPT code: 86052).

Methodology

Cell-based Immunofluorescence Assay

Assay Category

Reference Range(s)

Aquaporin 4 Ab, CBA, Serum	Negative
Aquaporin 4 Ab, Titer, Serum	<1:10 Titer

Alternative Name(s)

Transverse Myelitis Antibody,AQP4,NMO antibody,Aquaporin,LETM antibody,Optic Neuritis Antibody,Devic’s Antibody,NMO-IgG,Neuromyelitis Optica,NMOSD,AQP

LOINC® Codes, Performing Laboratory

Service Area must be determined

Preferred Specimen(s)

2 mL serum collected in a red-top tube (no gel)

Minimum Volume

0.5 mL

Transport Container

Transport tube

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: 7 days
Refrigerated: 14 days
Frozen: 21 days

Reject Criteria

Gross hemolysis • Grossly lipemic • Serum separator tube (SST)

Setup Schedule

Service Area must be determined

Preferred Specimen(s)

2 mL serum collected in a red-top tube (no gel)

Minimum Volume

0.5 mL

Transport Container

Transport tube

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: 7 days
Refrigerated: 14 days
Frozen: 21 days

Reject Criteria

Gross hemolysis • Grossly lipemic • Serum separator tube (SST)

Setup Schedule

Service Area must be determined

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.

In-home collection may be available in your area for purchase through Quest Mobile.

Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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