NMO Spectrum Evaluation (AQP4 with Reflex to MOG), CSF

NMO Spectrum Evaluation (AQP4 with Reflex to MOG), CSF

Test Code

38313
86052
38313
86052
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection is not available in your area through Quest Mobile.

Clinical Significance

NMO Spectrum Evaluation (AQP4 with Reflex to MOG), CSF - NMO (neuromyelitis optica, Devic disease) is an immune- mediated chronic inflammatory disease that predominantly affects the optic nerve and spinal cord and presents with optic neuritis (ON) and myelitis. Limited forms of this disease, such as isolated ON, brainstem encephalitis and longitudinal extensive transverses myelitis (LETM), have been referred to as NMO spectrum disorders (NMOSD). NMO was originally thought to be a variant of multiple sclerosis but is now recognized as a distinct disease. The presence of serum antibodies against aquaporin-4 (AQP4) or myelin oligodendrocyte glycoprotein (MOG-IgG) is associated with NMO and NMOSD.

Test Resources

Clinical Focus

Neuromyelitis Optica Spectrum Disorders: Laboratory Support of Diagnosis and Management

Test Details

Includes

  • If the Aquaporin 4 Antibody, CSF is positive, then Aquaporin 4 Antibody, Titer, CSF will be performed at an additional charge (CPT code: 86052).
  • If the Aquaporin 4 Antibody, CSF is negative, then MOG Antibody, CBA will be performed at an additional charge (CPT code: 86362).
  • If the MOG Antibody, CBA, CSF is positive, then MOG Antibody, Titer, CSF will be performed at an additional charge (CPT code: 86362).

Methodology

Cell-based Immunofluorescence Assay

Assay Category

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

Aquaporin 4 Ab, CBA, CSF Negative
  Aquaporin 4 Ab, Titer, CSF <1:10 Titer
  MOG Ab, CBA, CSF Negative
  MOG Ab, Titer, CSF <1:2 Titer

Alternative Name(s)

Transverse Myelitis Antibody,NMO Spectrum Disorder,NMO antibody,Aquaporin,Optic Neuritis Antibody,NMO-IgG,NMOSD,AQP,Myelin oligodendrocyte glycoprotein,MOG-IgG,MOG,AQP4,LETM antibody,AQP4 reflex MOG,Devic’s Antibody,Neuromyelitis Optica

LOINC® Codes, Performing Laboratory

Service Area must be determined
If the Aquaporin 4 Antibody, CSF is positive, then Aquaporin 4 Antibody, Titer, CSF will be performed at an additional charge (CPT code: 86052).
If the Aquaporin 4 Antibody, CSF is negative, then MOG Antibody, CBA will be performed at an additional charge (CPT code: 86362).
If the MOG Antibody, CBA, CSF is positive, then MOG Antibody, Titer, CSF will be performed at an additional charge (CPT code: 86362).

Methodology

Cell-based Immunofluorescence Assay
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

Aquaporin 4 Ab, CBA, CSF Negative
  Aquaporin 4 Ab, Titer, CSF <1:10 Titer
  MOG Ab, CBA, CSF Negative
  MOG Ab, Titer, CSF <1:2 Titer

Alternative Name(s)

Transverse Myelitis Antibody,NMO Spectrum Disorder,NMO antibody,Aquaporin,Optic Neuritis Antibody,NMO-IgG,NMOSD,AQP,Myelin oligodendrocyte glycoprotein,MOG-IgG,MOG,AQP4,LETM antibody,AQP4 reflex MOG,Devic’s Antibody,Neuromyelitis Optica
Service Area must be determined

Preferred Specimen(s)

2 mL CSF collected in a sterile plastic screw-cap vial

Minimum Volume

1 mL

Transport Container

Transport tube

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

  • Room temperature: 7 days
  • Refrigerated: 14 days
  • Frozen: 21 days

Reject Criteria

Visible particulate matter

Setup Schedule

Service Area must be determined
2 mL CSF collected in a sterile plastic screw-cap vial
1 mL
Transport tube
Refrigerated (cold packs)
Room temperature: 7 days
Refrigerated: 14 days
Frozen: 21 days
Visible particulate matter
Service Area must be determined
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection is not available in your area through Quest Mobile.
Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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