Myeloma Measurable Residual Disease (MRD) Detection, Flow Cytometry

Myeloma Measurable Residual Disease (MRD) Detection, Flow Cytometry

Test Code

38287
88184, 88185 (x10), 88188
38287
88184, 88185 (x10), 88188
Ordering Restrictions may apply. Please provide SERVICE AREA INFORMATION to find available tests you can order.
Not offered in Quest Nichols Institute - Chantilly, VA | Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano | Quest Nichols Institute -San Juan Capistrano, CA. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection may be available in your area for purchase through Quest Mobile.

Clinical Significance

Myeloma Measurable Residual Disease (MRD) Detection, Flow Cytometry - Next-generation flow cytometry (NGFC) is an ultra-sensitive tool for assessing measurable residual disease (MRD) in hematologic malignancies. MRD tests provide crucial prognostic information to clinicians, helping them evaluate treatment response and determine if a patient is in stable remission or relapse.

Test Resources

Test FAQ

Myeloma Measurable Residual Disease (MRD) Detection, Flow Cytometry

Test Details

Includes

  • Initial markers evaluated: CD19, CD20, CD27, CD38, CD45, CD56, CD81, CD117, CD138, CD200, CD229

    Additional markers may be performed based on the pathologist review. These markers will be performed at an additional charge (CPT code(s): 88185 for each additional marker).

Methodology

Flow Cytometry (FC)

Assay Category

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

This test is not available for New York patient testing.

Reference Range(s)

See Laboratory Report

Alternative Name(s)

Minimal Residual Disease,Hematologic Neoplasm,Leukemia,NGFC,Next Generation Flow Cytometry,Plasma Cell Neoplasm

LOINC® Codes, Performing Laboratory

Service Area must be determined
Initial markers evaluated: CD19, CD20, CD27, CD38, CD45, CD56, CD81, CD117, CD138, CD200, CD229

Additional markers may be performed based on the pathologist review. These markers will be performed at an additional charge (CPT code(s): 88185 for each additional marker).

Methodology

Flow Cytometry (FC)
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

This test is not available for New York patient testing.

Reference Range(s)

See Laboratory Report

Alternative Name(s)

Minimal Residual Disease,Hematologic Neoplasm,Leukemia,NGFC,Next Generation Flow Cytometry,Plasma Cell Neoplasm
Service Area must be determined

Preferred Specimen(s)

10 mL whole blood collected in two separate 5 mL sodium heparin (green-top) tubes

Minimum Volume

5 mL

Collection Instructions

Specimen viability decreases during transit. Send specimens to testing laboratory for viability determination. Do not freeze. Do not reject.

Follow standard whole blood collection procedure. Collect two 5 mL whole blood samples in sodium heparin (green-top) tubes. Blood samples are shipped at room temperature or 4° C. Do not freeze whole blood. Record the draw time and sample type on the tubes and on requisition form. Ship immediately to maintain specimen stability.

Protect from heat with a refrigerated cold (not frozen) pack.

Transport Container

Sodium heparin (green top) tube(s)

Transport Temperature

Room temperature

Specimen Stability

  • Room temperature: 5 days
    Refrigerated: 5 days
    Frozen: Unacceptable

Reject Criteria

Gross hemolysis

Setup Schedule

Service Area must be determined
10 mL whole blood collected in two separate 5 mL sodium heparin (green-top) tubes
5 mL
Specimen viability decreases during transit. Send specimens to testing laboratory for viability determination. Do not freeze. Do not reject.

Follow standard whole blood collection procedure. Collect two 5 mL whole blood samples in sodium heparin (green-top) tubes. Blood samples are shipped at room temperature or 4° C. Do not freeze whole blood. Record the draw time and sample type on the tubes and on requisition form. Ship immediately to maintain specimen stability.

Protect from heat with a refrigerated cold (not frozen) pack.
Sodium heparin (green top) tube(s)
Room temperature
Room temperature: 5 days
Refrigerated: 5 days
Frozen: Unacceptable
Gross hemolysis
Service Area must be determined
Ordering Restrictions may apply. Please provide SERVICE AREA INFORMATION to find available tests you can order.
Not offered in Quest Nichols Institute - Chantilly, VA | Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano | Quest Nichols Institute -San Juan Capistrano, CA. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection may be available in your area for purchase through Quest Mobile.
Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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