IA-2 Antibody

IA-2 Antibody

Test Code

37933
86341
37933
86341
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection may be available in your area for purchase through Quest Mobile.

Clinical Significance

IA-2 Antibody - Key clinical use and differentiators
Measurement of Islet cell antigen 2 antibodies (IA-2) is used to: 1. Screen for presymptomatic T1D in individuals with a family history of type 1 diabetes (T1D) or those known to have a high-risk HLA genotype, 2. Distinguish between T1D, type 2 diabetes mellitus (T2D), and atypical forms of diabetes such as latent autoimmune diabetes in adults (LADA). [1] Positivity to IA-2 represents a key marker of T1D. [1]

Intended Clinical Use
This test is crucial for differentiating between T1D and T2D. It is important to note that classifying diabetes type ...

Test Resources

Test FAQ

Autoantibodies and Type 1 Diabetes (T1D)

Algorithm

Staging presymptomatic patients using Diabetes Type 1 Autoantibody Panel

Test Summary

Diabetes Type 1 Autoantibody Panel

Test Details

Methodology

Enzyme Linked Immunosorbent Assay (ELISA)

Assay Category

Reference Range(s)

<5.4 U/mL

Alternative Name(s)

Tyrosine Phosphatase,ICA 512 Antibody,Insulinoma-associated Protein 2,Islet Cell Antigen 512 Antibodies

LOINC® Codes, Performing Laboratory

Service Area must be determined

Methodology

Enzyme Linked Immunosorbent Assay (ELISA)

Reference Range(s)

<5.4 U/mL

Alternative Name(s)

Tyrosine Phosphatase,ICA 512 Antibody,Insulinoma-associated Protein 2,Islet Cell Antigen 512 Antibodies
Service Area must be determined

Preferred Specimen(s)

1 mL serum

Minimum Volume

0.5 mL

Transport Container

Transport tube

Transport Temperature

Room temperature

Specimen Stability

  • Room temperature: 7 days
  • Refrigerated: 7 days
  • Frozen: 30 days

Reject Criteria

Gross hemolysis • Grossly lipemic

Setup Schedule

Service Area must be determined
1 mL serum
0.5 mL
Transport tube
Room temperature
Room temperature: 7 days
Refrigerated: 7 days
Frozen: 30 days
Gross hemolysis • Grossly lipemic
Service Area must be determined
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection may be available in your area for purchase through Quest Mobile.
Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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